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https://ahro.austin.org.au/austinjspui/handle/1/16110| Title: | Mortality in mild cognitive impairment: A longitudinal study in memory clinics | Austin Authors: | Connors, Michael H;Ames, David;Boundy, Karyn;Clarnette, Roger;Kurrle, Sue;Mander, Alastair G;Ward, John;Woodward, Michael M ;Brodaty, Henry | Affiliation: | Austin Health, Heidelberg, Victoria, Australia Dementia Collaborative Research Centre, School of Psychiatry, UNSW Australia, Sydney, NSW, Australia Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia Academic Unit for Psychiatry of Old Age, The University of Melbourne, Parkville, Victoria, Australia National Ageing Research Institute, Melbourne, Victoria, Australia The Queen Elizabeth Hospital, Adelaide, South Australia, Australia School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia Sydney Medical School, University of Sydney, Sydney, NSW, Australia Faculty of Health, Deakin University, Geelong, Victoria, Australia School of Medicine and Population Health, University of Newcastle, Newcastle, NSW, Australia |
Issue Date: | 27-Jul-2016 | Date: | 2016-07-27 | Publication information: | Journal of Alzheimer's Disease 2016; 54(1): 149-155 | Abstract: | Background: Patients with mild cognitive impairment (MCI) are at greater risk of mortality than the general population. Comparatively little research has examined predictors of mortality in MCI and no research has examined whether time-varying variables, such as change in cognition and function, predict survival. Objective: To identify predictors of mortality in patients with MCI. Methods: 185 patients with MCI were recruited from nine memory clinics around Australia. Patients completed measures of cognition, function, and neuropsychiatric symptoms over three years. Mortality data were obtained from state registries eight years after baseline. Results: 55 (30%) patients died within this period. Older age, lower cognitive and functional ability at baseline, and greater decline in functional ability over six months predicted mortality. Conclusion: Easily measurable clinical data predict mortality in patients with MCI. Longitudinal assessment over time can provide additional information about patients’ risk. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/16110 | DOI: | 10.3233/JAD-160148 | Journal: | Journal of Alzheimer's Disease | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/27472874 | Type: | Journal Article | Subjects: | Lifespan Longitudinal Studies Mild cognitive impairment Mortality Risk Factors Survival |
| Appears in Collections: | Journal articles |
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