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Title: Mortality in mild cognitive impairment: A longitudinal study in memory clinics
Austin Authors: Connors, Michael H;Ames, David;Boundy, Karyn;Clarnette, Roger;Kurrle, Sue;Mander, Alastair G;Ward, John;Woodward, Michael M ;Brodaty, Henry
Affiliation: Austin Health, Heidelberg, Victoria, Australia
Dementia Collaborative Research Centre, School of Psychiatry, UNSW Australia, Sydney, NSW, Australia
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia
Academic Unit for Psychiatry of Old Age, The University of Melbourne, Parkville, Victoria, Australia
National Ageing Research Institute, Melbourne, Victoria, Australia
The Queen Elizabeth Hospital, Adelaide, South Australia, Australia
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
Sydney Medical School, University of Sydney, Sydney, NSW, Australia
Faculty of Health, Deakin University, Geelong, Victoria, Australia
School of Medicine and Population Health, University of Newcastle, Newcastle, NSW, Australia
Issue Date: 27-Jul-2016 2016-07-27
Publication information: Journal of Alzheimer's Disease 2016; 54(1): 149-155
Abstract: Background: Patients with mild cognitive impairment (MCI) are at greater risk of mortality than the general population. Comparatively little research has examined predictors of mortality in MCI and no research has examined whether time-varying variables, such as change in cognition and function, predict survival. Objective: To identify predictors of mortality in patients with MCI. Methods: 185 patients with MCI were recruited from nine memory clinics around Australia. Patients completed measures of cognition, function, and neuropsychiatric symptoms over three years. Mortality data were obtained from state registries eight years after baseline. Results: 55 (30%) patients died within this period. Older age, lower cognitive and functional ability at baseline, and greater decline in functional ability over six months predicted mortality. Conclusion: Easily measurable clinical data predict mortality in patients with MCI. Longitudinal assessment over time can provide additional information about patients’ risk.
DOI: 10.3233/JAD-160148
PubMed URL:
Type: Journal Article
Subjects: Lifespan
Longitudinal Studies
Mild cognitive impairment
Risk Factors
Appears in Collections:Journal articles

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