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Title: Identifying and targeting determinants of melanoma cellular invasion
Austin Authors: Jayachandran, Aparna;Prithviraj, Prashanth;Lo, Pu-Han;Walkiewicz, Marzena;Anaka, Matthew;Woods, Briannyn;Behren, Andreas;Cebon, Jonathan S ;McKeown, SJ
Affiliation: Olivia Newton-John Cancer Research Institute, Olivia Newton-John Cancer and Wellness Centre, Heidelberg, Victoria, Australia
Ludwig Institute for Cancer Research, Melbourne-Austin Branch, Victoria, Australia
Department of Medicine, University of Melbourne, Victoria, Australia
School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia
The University of Queensland School of Medicine and the Gallipoli Medical Research Institute, Greenslopes Private Hospital, Brisbane, Queensland, Australia
Department of Anatomy and Neuroscience, University of Melbourne, Victoria, Australia
Issue Date: Jul-2016
Publication information: Oncotarget 2016; 7(27): 41186-41202
Abstract: Epithelial-to-mesenchymal transition is a critical process that increases the malignant potential of melanoma by facilitating invasion and dissemination of tumor cells. This study identified genes involved in the regulation of cellular invasion and evaluated whether they can be targeted to inhibit melanoma invasion. We identified Peroxidasin (PXDN), Netrin 4 (NTN4) and GLIS Family Zinc Finger 3 (GLIS3) genes consistently elevated in invasive mesenchymal-like melanoma cells. These genes and proteins were highly expressed in metastatic melanoma tumors, and gene silencing led to reduced melanoma invasion in vitro. Furthermore, migration of PXDN, NTN4 or GLIS3 siRNA transfected melanoma cells was inhibited following transplantation into the embryonic chicken neural tube compared to control siRNA transfected melanoma cells. Our study suggests that PXDN, NTN4 and GLIS3 play a functional role in promoting melanoma cellular invasion, and therapeutic approaches directed toward inhibiting the action of these proteins may reduce the incidence or progression of metastasis in melanoma patients.
DOI: 10.18632/oncotarget.9227
Journal: Oncotarget
PubMed URL:
Type: Journal Article
Subjects: Transplantation
Epithelial-Mesenchymal Transition
Appears in Collections:Journal articles

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