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Title: Glaucarubinone combined with gemcitabine improves pancreatic cancer survival in an immunocompetent orthotopic murine model
Austin Authors: Yeo, Dannel;Huynh, Nhi;Beutler, John A;Baldwin, Graham S;He, Hong ;Nikfarjam, Mehrdad 
Affiliation: Department of Surgery, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Molecular Targets Laboratory, National Cancer Institute, Frederick, MD, USA
Issue Date: Dec-2016
Date: 2016-03-30
Publication information: Journal of Investigative Surgery 2016; 29(6): 366-372
Abstract: BACKGROUND: Pancreatic cancer continues to have a poor survival rate with an urgent need for improved treatments. Glaucarubinone, a natural product first isolated from the seeds of the tree Simarouba glauca, has recently been recognized as having anti-cancer properties that may be particularly applicable to pancreatic cancer. METHODS: The effect of glaucarubinone on the growth and migration of murine pancreatic cancer cells was assessed by 3H-thymidine incorporation assay. The survival impact of glaucarubinone alone and in combination with gemcitabine chemotherapy was assessed using an immunocompetent orthotopic murine model of pancreatic cancer. RESULTS: Glaucarubinone inhibited the growth of the murine pancreatic cancer cell lines LM-P and PAN02. Treatment with either glaucarubinone or gemcitabine reduced proliferation in vitro and the combination was synergistic. The combination treatment improved survival two-fold compared to gemcitabine treatment alone (p = 0.046) in PAN02 cells. CONCLUSIONS: The synergistic inhibition by glaucarubinone and gemcitabine observed in vitro and the improved survival in vivo suggest that glaucarubinone may be a useful adjunct to current chemotherapy regimens
ORCID: 0000-0002-0944-8747
Journal: Journal of Investigative Surgery
PubMed URL:
Type: Journal Article
Subjects: Gemcitabine
Prostatic Neoplasms
Appears in Collections:Journal articles

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