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Title: Evidence for 5-HT1A receptor control of pineal melatonin concentrations in the rat.
Austin Authors: Nathan, P J;Burrows, Graham D;Norman, Trevor R 
Affiliation: Department of Psychiatry, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Australia
Issue Date: 1-Aug-1998
Publication information: European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology; 8(3): 183-6
Abstract: The effect of some serotonin agonists on day and night-time melatonin in the pineal gland was investigated in male rats. Dose dependent increases in nocturnal melatonin concentrations were observed for all serotonin agonists investigated. Statistically significant increases were observed only for D-fenfluramine (20 mg/kg) and the full 5-HT1A agonists S(+)-20499 (10 mg/kg, 20 mg/kg) and flesinoxan (20 mg/kg). Both paroxetine and D-fenfluramine dose dependently increased day-time pineal melatonin, but only for D-fenfluramine (20 mg/kg) was there a statistically significant increase. The data suggest that acute increases in synaptic serotonin concentrations can be used to manipulate day- or night-time melatonin. Data suggests an influence of the 5-HT1A receptor subtype in mediating nocturnal melatonin concentrations, perhaps through a functional coupling to beta1-adrenoceptors on the pineal gland.
Gov't Doc #: 9716310
Type: Journal Article
Subjects: Animals
Circadian Rhythm.drug effects.physiology
Pineal Gland.drug effects.physiology
Rats, Sprague-Dawley
Receptors, Serotonin.drug effects.physiology
Serotonin Receptor Agonists.pharmacology
Appears in Collections:Journal articles

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