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Title: Aggravation of generalized epilepsies.
Austin Authors: Berkovic, Samuel F 
Affiliation: Department of Medicine (Neurology), University of Melbourne, and Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
Issue Date: 16-May-1998
Publication information: Epilepsia; 39 Suppl 3(): S11-4
Abstract: Generalized epilepsies are treatable with a number of antiepileptic drugs (AEDs) that are effective in different seizure types and epilepsy syndromes. The mechanisms of action of these AEDs are incompletely understood but include inhibition of low-threshold calcium currents and of voltage-gated sodium channels and facilitation of GABA(A) receptor currents. The mechanisms of aggravation are also unknown but could include elevation of brain GABA, blockade of voltage-gated sodium channels, and idiosyncratic toxicity reactions. Anecdotal reports suggest that aggravation of generalized epilepsy can occur with virtually all AEDs. The best-documented examples are aggravation of absences by carbamazepine and aggravation of symptomatic generalized epilepsies by vigabatrin. Therefore, the physician must be constantly aware of the problem of aggravation of seizures by AEDs. With careful diagnosis of the epileptic syndrome and an awareness of the problem, aggravation of seizures can be minimized.
Gov't Doc #: 9593230
Type: Journal Article
Subjects: Acute Disease
Anticonvulsants.adverse effects.therapeutic use
Carbamazepine.adverse effects.therapeutic use
Epilepsy, Generalized.chemically induced.classification.drug therapy
gamma-Aminobutyric Acid.adverse effects.analogs & derivatives.therapeutic use
Appears in Collections:Journal articles

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