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Title: A study of the interactive effects of oral contraceptive use and dietary fat intake on blood pressure, cardiovascular reactivity and glucose tolerance in normotensive women.
Austin Authors: Straznicky, N E;Barrington, V E;Branley, P;Louis, William J 
Affiliation: Department of Medicine, University of Melbourne, Austin Repatriation Medical Centre, Heidelberg, Victoria, Australia
Issue Date: 1-Mar-1998
Publication information: Journal of Hypertension; 16(3): 357-68
Abstract: To investigate the interactive effects of oral contraceptive pill use and dietary fat intake on cardiovascular haemodynamics and metabolic parameters in young normotensive women.Thirty-two women participated, of whom 16 were taking oral contraceptive pills (ethinyl-oestradiol plus levonorgestrel) and 16 were age-matched and weight-matched controls not taking such pills. Subjects consumed either a high-fat or a low-fat diet for 2 weeks in an open, randomized, crossover study lasting 6 weeks. Investigations were performed at the end of each diet during the luteal phase of the menstrual cycle.Blood pressure was measured by 24 h ambulatory recording; cardiovascular reactivity was determined by examining blood pressure responses to systemic infusions of noradrenaline and angiotensin II and to the cold pressor test; and carbohydrate metabolism was investigated by an intravenous glucose-tolerance test.Plasma triglyceride levels were significantly higher in women taking oral contraceptive pills compared with non-users on both diets; however, responses of lipoprotein levels to the two diets did not differ between study groups (total and low-density lipoprotein cholesterol levels decreased by 15 and 17% in oral contraceptive pill users and by 14% each in non-users, on the low-fat compared with the high-fat diet). Fasting plasma insulin levels, the insulin-production response to administration of glucose (insulin area under the curve) and resting clinic and night-time systolic blood pressures were all significantly reduced on the low-fat diet, but only in non-users. Blood pressure responses to noradrenaline and maximal heart rate response to cold were significantly attenuated during the low-fat diet in oral contraceptive pill users. During the low-fat diet, resting systolic, 24 h systolic and diastolic blood pressures and insulin area under the curve were all significantly higher for women taking the oral contraceptive pills. Users of these pills also exhibited a greater systolic sensitivity to administration both of noradrenaline and of angiotensin II and had a higher plasma renin activity irrespective of dietary phase.These results confirm that oral contraceptive pills have the potential to cause adverse effects on blood pressure, cardiovascular reactivity and the insulin-production response to administration of glucose and suggest that some of the beneficial effects of a low-fat diet on these parameters may be negated in women taking oral contraceptive pills.
Gov't Doc #: 9557929
Journal: Journal of Hypertension
Type: Journal Article
Subjects: Australia
Blood Pressure
Carbohydrate Metabolic Effects
Cardiovascular Effects
Clinical Research
Contraceptive Methods--side effects
Developed Countries
Examinations And Diagnoses
Family Planning
Glucose Metabolism Effects
Hemic System
Laboratory Examinations And Diagnoses
Laboratory Procedures
Metabolic Effects
Oral Contraceptives, Combined--side effects
Oral Contraceptives--side effects
Research Methodology
Research Report
Blood Glucose.metabolism
Blood Pressure.drug effects
Cardiovascular System.drug effects
Contraceptives, Oral.adverse effects
Cross-Over Studies
Diet, Fat-Restricted
Dietary Fats.administration & dosage.adverse effects
Glucose Tolerance Test
Heart Rate
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