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Title: Epilepsies in twins: genetics of the major epilepsy syndromes.
Austin Authors: Berkovic, Samuel F ;Howell, R A;Hay, D A;Hopper, John L
Affiliation: Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg (Melbourne), Victoria, Australia
Issue Date: 1-Apr-1998
Publication information: Annals of Neurology; 43(4): 435-45
Abstract: We studied twins to examine the genetics of epilepsy syndromes. We ascertained 358 twin pairs in whom one or both reported seizures. After evaluation, 253 of 358 (71%) had seizure disorders and 105 pairs were false positives. Among the monozygous (MZ) pairs, more were concordant for seizures (48 of 108; casewise concordance = 0.62 +/- 0.05) than among the dizygous (DZ) pairs (14 of 145; casewise concordance = 0.18 +/- 0.04). In 94% of concordant MZ pairs, and 71% of concordant DZ pairs, both twins had the same major epilepsy syndrome. When analyzed according to major epilepsy syndrome, the casewise concordances for generalized epilepsies (MZ = 0.82; DZ = 0.26), both idiopathic (MZ = 0.76; DZ = 0.33) and symptomatic (MZ = 0.83; DZ = 0), were greater than those for partial epilepsies (MZ = 0.36; DZ = 0.05), with intermediate values seen for febrile seizures (MZ = 0.58; DZ = 0.14) and unclassified epilepsies (MZ = 0.53; DZ = 0.18). We conclude that genetic factors are particularly important in the generalized epilepsies but also play a role in the partial epilepsies. The high frequency of concordant MZ pairs with the same major syndrome strongly suggests there are syndrome-specific genetic determinants rather than a broad genetic predisposition to seizures.
Gov't Doc #: 9546323
DOI: 10.1002/ana.410430405
Type: Journal Article
Subjects: Analysis of Variance
Diseases in Twins.genetics
Longitudinal Studies
Sex Characteristics
Twins, Dizygotic
Twins, Monozygotic
Appears in Collections:Journal articles

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