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Title: New hormonal blockade strategies in cardiovascular disease.
Austin Authors: Johnston, Colin I;Naitoh, M;Risvanis, John;Farina, N K;Burrell, Louise M 
Affiliation: Department of Medicine, University of Melbourne, Austin & Repatriation Medical Centre, Heidelberg, Victoria, Australia
Issue Date: 16-May-1998
Publication information: Scandinavian Cardiovascular Journal. Supplement; 47(): 61-6
Abstract: The circulation is controlled by overlapping haemodynamic, structural and neurohumoral mechanisms. Many hormonal vasoactive substances, mostly derived from endothelial cells, are also growth regulators. Although neurohormonal systems are involved in normal physiological compensatory responses they often become maladaptive in conditions such as congestive heart failure. The success of blocking the renin angiotensin system by angiotensin converting enzyme (ACE) inhibitors has led to efforts to block other hormonal systems. Neutral endopeptidase (NEP), the major enzymatic pathway for degradation of natriuretic peptides, has a similar catalytic site to ACE. This has led to compounds that simultaneously inhibit both enzymes. Such dual ACE/NEP inhibitors show promise in experimental hypertension and heart failure. Similar dual NEP/ECE (endothelin converting enzyme) inhibitors are becoming available. The hormone vasopressin has dual actions on the vasculature and the kidney via specific membrane receptors. Specific orally active vasopressin receptor antagonists have been developed and their therapeutic potential in hypertension, heart failure and oedematous states are being explored.
Gov't Doc #: 9540135
Journal: Scandinavian cardiovascular journal. Supplement
Type: Journal Article
Subjects: Angiotensin-Converting Enzyme Inhibitors.therapeutic use
Cardiovascular Diseases.drug therapy.metabolism
Hormone Antagonists.therapeutic use
Metalloendopeptidases.antagonists & inhibitors.metabolism
Peptides.antagonists & inhibitors.metabolism
Vasopressins.antagonists & inhibitors.metabolism
Appears in Collections:Journal articles

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