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Title: Chronic vasopressin antagonism in two-kidney, one-clip renovascular hypertension.
Austin Authors: Burrell, Louise M ;Risvanis, John;Phillips, P A;Naitoh, M;Johnston, Colin I
Affiliation: Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Hospital, Victoria, Australia
Issue Date: 8-Jul-1997
Publication information: Clinical and Experimental Hypertension (new York, N.y. : 1993); 19(5-6): 981-91
Abstract: The role of vasopressin (AVP) in the maintenance of hypertension in the rat model of two-kidney, one-clip (2K1C) Goldblatt hypertension was assessed using the nonpeptide orally effective V1a receptor antagonist, OPC-21268. Rats were studied eight weeks after surgery when mean arterial pressure (MAP) was significantly increased in 2K1C rats compared to SHAM operated controls (2K1C 139 +/- 6, SHAM 106 +/- 3, P < 0.01). Neither acute (OPC-21268, 30 mg/kg) nor chronic (OPC-21268, 30 mg/kg twice daily) V1a receptor blockade reduced blood pressure in either 2K1C or SHAM rats. The results of binding kinetic studies confirmed that OPC-21268 was effective at its putative site of action, the V1a receptor in both 2K1C and SHAM rats. These results indicate AVP is not involved in the maintenance of blood pressure in the 2K1C model of renovascular hypertension.
Gov't Doc #: 9247769
Type: Journal Article
Subjects: Animals
Antidiuretic Hormone Receptor Antagonists
Arginine Vasopressin.antagonists & inhibitors.physiology
Blood Pressure.drug effects
Hypertension, Renovascular.drug therapy.metabolism.physiopathology
Rats, Sprague-Dawley
Receptors, Vasopressin.metabolism
Appears in Collections:Journal articles

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