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Title: Epidermal growth factor and fluid and electrolyte balance in the rat.
Austin Authors: Grant, Sharon L;Gow, Paul J ;Phillips, P A
Affiliation: Medicine (University of Melbourne)
Issue Date: 1-Jun-1997
Publication information: The American Journal of Physiology; 272(6 Pt 2): R1853-61
Abstract: Epidermal growth factor (EGF) has been shown to induce a renal diuresis and natriuresis in sheep and stimulate prostaglandin synthesis from inner rat medullary collecting duct cells in culture. The aims of our study were 1) to investigate whether the renal effects of intravenous infusion of EGF were species specific and 2) to determine the mechanism of these effects by studying the interaction between EGF and indomethacin (a prostaglandin synthase inhibitor) in the conscious rat. Sprague-Dawley rats received intravenous infusions of either 0.9% saline or 0.2 or 2.0 micrograms over a 6-day period after an initial baseline period. Infusion of 2.0 micrograms caused an increase in urine volume (baseline: 5.5 +/- 0.2 ml to day 5: 9.0 +/- 0.4 ml, P < 0.01) and corresponding polydipsia, but not natriuresis. Administration of indomethacin with 2.0 micrograms attenuated (P < 0.05) the diuretic (day 5 EGF + vehicle: 12.2 +/- 1.1 ml vs. EGF + indomethacin: 8.7 +/- 0.9 ml) and polydipsic effects of EGF. These studies demonstrate that intravenous infusion of EGF causes a diuretic effect in rats without natriuresis and that prostaglandins play a role in the diuretic effect of EGF in the rat.
Journal: American Journal of Physiology
Type: Journal Article
Subjects: Animals
Blood Pressure.drug effects
Body Fluids.metabolism
Epidermal Growth Factor.pharmacology.urine
Glomerular Filtration Rate.drug effects
Prostaglandin Antagonists.pharmacology
Rats, Sprague-Dawley
Appears in Collections:Journal articles

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