Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13402
Title: Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9.
Austin Authors: Sandrin, Mauro S ;Henning, M M;Lo, M F;Baker, E;Sutherland, G R;McKenzie, Ian F C
Affiliation: Molecular Immunogenetics Laboratory, Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 16-May-1996
Publication information: Immunogenetics; 43(1-2): 13-9
Abstract: Ly9 is a mouse cell membrane antigen found on all lymphocytes and coded for by a gene that maps to chromosome 1. We previously described the isolation and characterization of a full-length cDNA clone for mouse Ly9. Using cross-species hybridization we isolated cDNA clones encoding the human homologue Humly9. Analysis of the predicted protein sequence suggests that the extra-cellular portion of the Humly9 molecules is composed of four Ig-like domains: a V domain (V) without disulphide bonds and a truncated C2 domain (tC2) with two disulphide bonds, a second V domain without disulphide bonds and a second tC2 with two disulphide bonds, i.e., as V-tC2-V-tC2. The gene encoding Humly9 was mapped to chromosome 1 by analysis of human/hamster hybrids, and more specifically to the 1q22 region by in situ hybridization. The protein sequence data support the view that Humly9 belongs to the immunoglobulin-superfamily subgroup which includes CD48, CD2, and LFA-3.
Gov't Doc #: 8537117
URI: http://ahro.austin.org.au/austinjspui/handle/1/13402
URL: https://pubmed.ncbi.nlm.nih.gov/8537117
Type: Journal Article
Subjects: Amino Acid Sequence
Animals
Antigens, Ly.genetics
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 1
Cricetinae
DNA, Complementary.genetics
Gene Library
Genes
Humans
Hybrid Cells
In Situ Hybridization, Fluorescence
Mice
Molecular Sequence Data
Multigene Family
Sequence Alignment
Sequence Homology, Amino Acid
Species Specificity
Appears in Collections:Journal articles

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