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Title: The effects of perindopril and triple therapy in a normotensive model of diabetic nephropathy.
Austin Authors: O'Brien, R C;Cooper, Mark E;Jerums, George ;Doyle, A E
Affiliation: Department of Endocrinology, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Apr-1993
Publication information: Diabetes; 42(4): 604-9
Abstract: The effect of the angiotensin-converting enzyme inhibitor, perindopril, on functional and structural parameters of diabetic nephropathy has been compared with triple therapy (hydralazine, reserpine, and hydrochlorothiazide) in normotensive, STZ-induced diabetic Sprague-Dawley rats. Animal groups included control rats, diabetic rats treated with perindopril, diabetic rats receiving triple therapy, and untreated diabetic rats. Treatment was continued for 32 wk. Blood pressure reduction and severity of diabetes, as assessed by body weight and glycemic control were similar with both drug regimens. A similar rise in plasma renin activity occurred in the two groups receiving antihypertensive drugs, whereas the perindopril but not the triple therapy group had suppressed plasma angiotensin-converting enzyme activity. No significant difference was observed in renal function among the four groups. Diabetes was associated with a progressive increase in albuminuria, but this rise was ameliorated by both perindopril and triple therapy. No significant difference was noted in albuminuria between triple therapy and perindopril-treated diabetic rats. Diabetes was associated with glomerular basement membrane thickening, mesangial expansion, and glomerular volume. No glomerular ultrastructural parameter was affected by antihypertensive drugs. No specific benefit of angiotensin-converting enzyme inhibition over triple therapy could be detected in this normotensive model of diabetic nephropathy.
Gov't Doc #: 8454112
Type: Journal Article
Subjects: Analysis of Variance
Angiotensin-Converting Enzyme Inhibitors.therapeutic use
Blood Glucose.metabolism
Blood Pressure.drug effects
Body Weight.drug effects
Diabetes Mellitus, Experimental.blood.physiopathology
Diabetic Nephropathies.blood.drug therapy
Drug Therapy, Combination
Glomerular Filtration Rate
Glomerular Mesangium.drug effects.pathology
Hydralazine.therapeutic use
Hydrochlorothiazide.therapeutic use
Indoles.therapeutic use
Kidney Glomerulus.drug effects.pathology
Rats, Sprague-Dawley
Reserpine.therapeutic use
Appears in Collections:Journal articles

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