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Title: Prolactin response to dl-fenfluramine in panic disorder.
Austin Authors: Apostolopoulos, M;Judd, F K;Burrows, Graham D;Norman, Trevor R 
Affiliation: University of Melbourne, Department of Psychiatry, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 16-May-1993
Publication information: Psychoneuroendocrinology; 18(5-6): 337-42
Abstract: The objective of this study was to test the hypothesis that serotonin receptors are hypersensitive in patients with panic disorder. Eleven patients and 12 controls received a single PO dose of 60 mg of dl-fenfluramine at 0900h on a single occasion. Blood samples were collected with an indwelling intravenous catheter at 30-min intervals from 0930h to 1530h and prolactin determined by radioimmunoassay. In both groups, fenfluramine induced a rise in the plasma prolactin concentration from baseline. The patients showed a greater increase in prolactin response than the normal controls. This result is consistent with the hypothesis of increased serotonin receptor function in patients with panic disorder.
Gov't Doc #: 8416044
Journal: Psychoneuroendocrinology
Type: Journal Article
Subjects: Administration, Oral
Fenfluramine.diagnostic use
Middle Aged
Panic Disorder.diagnosis.physiopathology.psychology
Receptors, Serotonin.drug effects.physiology
Appears in Collections:Journal articles

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