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https://ahro.austin.org.au/austinjspui/handle/1/13359| Title: | Prolactin response to dl-fenfluramine in panic disorder. | Austin Authors: | Apostolopoulos, M;Judd, F K;Burrows, Graham D;Norman, Trevor R | Affiliation: | University of Melbourne, Department of Psychiatry, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 16-May-1993 | Publication information: | Psychoneuroendocrinology; 18(5-6): 337-42 | Abstract: | The objective of this study was to test the hypothesis that serotonin receptors are hypersensitive in patients with panic disorder. Eleven patients and 12 controls received a single PO dose of 60 mg of dl-fenfluramine at 0900h on a single occasion. Blood samples were collected with an indwelling intravenous catheter at 30-min intervals from 0930h to 1530h and prolactin determined by radioimmunoassay. In both groups, fenfluramine induced a rise in the plasma prolactin concentration from baseline. The patients showed a greater increase in prolactin response than the normal controls. This result is consistent with the hypothesis of increased serotonin receptor function in patients with panic disorder. | Gov't Doc #: | 8416044 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/13359 | Journal: | Psychoneuroendocrinology | URL: | https://pubmed.ncbi.nlm.nih.gov/8416044 | Type: | Journal Article | Subjects: | Administration, Oral Adult Female Fenfluramine.diagnostic use Humans Male Middle Aged Panic Disorder.diagnosis.physiopathology.psychology Prolactin.blood Receptors, Serotonin.drug effects.physiology |
| Appears in Collections: | Journal articles |
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