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Title: Body composition following hemodialysis: studies using dual-energy X-ray absorptiometry and bioelectrical impedance analysis.
Austin Authors: Formica, C;Atkinson, M G;Nyulasi, I;McKay, J;Heale, W;Seeman, Ego 
Affiliation: Department of Endocrinology and Medicine, Austin Hospital, Melbourne, Australia
Issue Date: 1-Jul-1993
Publication information: Osteoporosis International : A Journal Established As Result of Cooperation Between the European Foundation For Osteoporosis and the National Osteoporosis Foundation of The Usa; 3(4): 192-7
Abstract: The detection, prevention and treatment of disease is greatly facilitated by the availability of accurate and non-invasive techniques for measuring the amount and regional distribution of fat mass and fat-free mass. As differing degrees of hydration may influence these measurements, we used dual-energy X-ray absorptiometry (DXA) and bioelectrical impedance analysis (BIA) to detect changes in hydration following hemodialysis, and to determine whether fat mass, fat-free mass and bone density measurements were affected by these fluid changes. Ten subjects (7 men, 3 women) mean age 46.2 years (range 25-68 years), with renal failure had bone density, fat-free mass and fat mass measured by DXA, and total body water and fat-free mass measured by BIA, before and after hemodialysis. Thirty-two subjects had fat-free mass measured by DXA and BIA in an attempt to derive new equations (using fat-free mass measured by DXA as the reference standard) to improve the predictive value of BIA. The new equations were then used to derive the changes in fat-free mass following hemodialysis measured using BIA. In absolute terms, total tissue measured by DXA (r = 0.99, p = 0.01) and total body water measured by BIA (r = 0.91, p = 0.01) correlated with gravimetric weight. Following hemodialysis, fat mass and bone density measured by DXA were unaffected by the fluid changes. The change in gravimetric weight was 1.8 +/- 0.3 kg, p = 0.01 (mean +/- SEM). This change was measured as 1.9 +/- 0.3 kg by DXA, -0.9 +/- 1.0 kg by BIA using the published equation for fat-free mass, and 3.2 +/- 0.4 kg using the new equation for fat-free mass.(ABSTRACT TRUNCATED AT 250 WORDS)
Gov't Doc #: 8338974
Journal: Osteoporosis International
Type: Journal Article
Subjects: Absorptiometry, Photon
Adipose Tissue
Body Composition
Body Water
Bone Density
Electric Impedance
Middle Aged
Renal Dialysis
Renal Insufficiency.therapy
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