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Title: Dopa resistance in multiple-system atrophy: loss of postsynaptic D2 receptors.
Austin Authors: Churchyard, A;Donnan, Geoffrey A ;Hughes, Andrew J ;Howells, David William;Woodhouse, D;Wong, J Y;Kalnins, Renate M;Mendelsohn, Frederick AO;Paxinos, G
Affiliation: Department of Neurology, Austin Hospital, Victoria, Australia
Issue Date: 1-Aug-1993
Publication information: Annals of Neurology; 34(2): 219-26
Abstract: Postmortem autoradiography was used to explore the mechanisms underlying L-dopa resistance in 2 patients with multiple-system atrophy. Indices of striatal presynaptic dopamine terminal loss and dopamine (D1 and D2) receptors were provided by 3H-mazindol, 3H-SCH 23390, and 125I-sulpiride binding. Neuronal loss, gliosis, and loss of postsynaptic D2 receptors preferentially involved the middle and posterior of the putamen, that region of the striatum most intimately involved in motor function. Loss of D1 receptors in the same area occurred in only 1 patient. These findings suggest that in multiple-system atrophy, resistance to L-dopa is due to a loss of putamental D2 receptors. The differential effects on D1 and D2 receptors in 1 patient implies that different subpopulations of striatal neurons were selectively involved.
Gov't Doc #: 8338346
DOI: 10.1002/ana.410340219
Journal: Annals of Neurology
Type: Journal Article
Subjects: Aged
Corpus Striatum.metabolism.pathology
Drug Resistance
Levodopa.therapeutic use
Parkinson Disease.drug therapy.metabolism.pathology
Receptors, Dopamine D1.analysis
Receptors, Dopamine D2.analysis
Appears in Collections:Journal articles

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