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Title: Anti-neutrophil cytoplasm antibodies in HIV infection.
Austin Authors: Savige, Judy A;Chang, L;Crowe, S M
Affiliation: University Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 16-May-1993
Publication information: Advances in Experimental Medicine and Biology; 336(): 349-52
Abstract: Sera from 105 HIV-infected patients were tested for anti-neutrophil cytoplasm antibodies (ANCA) by indirect immunofluorescence (IIF), by specific ELISAs using target proteins of ANCA and by a neutrophil cytoplasm extract ELISA. Forty-four sera were positive. These included 18 positive by IIF, 7 with anti-neutrophil proteinase 3 antibodies, 26 with anti-myeloperoxidase antibodies and 2 with anti-elastase antibodies. Four sera were positive in the neutrophil cytoplasm extract ELISA but not in the specific ELISAs. None of these patients had clinical evidence of a cutaneous or systemic vasculitis. In addition there was no correlation between the presence of ANCA and the stage of disease, intercurrent bacterial or viral infection, anti-nuclear antibodies (ANA) and positive hepatitis B or syphilis serology.
Gov't Doc #: 8296633
Type: Journal Article
Subjects: AIDS-Related Complex.immunology
Acquired Immunodeficiency Syndrome.immunology
Antibodies, Antineutrophil Cytoplasmic
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique
HIV Infections.immunology
Immunoglobulin G.blood
Pancreatic Elastase.immunology
Serine Endopeptidases.immunology
Appears in Collections:Journal articles

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