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Title: Effects of anti-emetics on water excretion in humans.
Austin Authors: Phillips, P A;Burrell, Louise M ;Risvanis, John;Stephenson, J;Johnston, Colin I;Hutchins, A M
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Jan-1994
Publication information: Clinical and Experimental Pharmacology & Physiology; 21(1): 59-62
Abstract: 1. The anti-emetic drug metoclopramide has been shown to stimulate secretion of the antidiuretic hormone arginine vasopressin. Since metoclopramide is used to treat nausea, which is another potent stimulus to vasopressin secretion, the aim of this study was to determine whether metoclopramide might limit free water excretion and so cause hyponatraemia. 2. Metoclopramide 20 mg (0.2-0.3 mg/kg), prochlorperazine 12.5 mg (0.1-0.2 mg/kg) and placebo were administered intravenously in a double blind randomized crossover way at 2 week intervals and the effects on urine flow rate, plasma osmolality, thirst ratings and plasma sodium and atrial natriuretic peptide concentrations determined in water-loaded (10 mL/kg) healthy young men. 3. There were no differential effects on any variable of either drug versus placebo. 4. These results indicate that metoclopramide is unlikely to cause any significant water retention in a clinical setting or precipitate hyponatraemia.
Gov't Doc #: 8156653
Type: Journal Article
Subjects: Adult
Atrial Natriuretic Factor.blood
Body Water.metabolism
Double-Blind Method
Injections, Intravenous
Metoclopramide.administration & dosage.pharmacology
Osmolar Concentration
Prochlorperazine.administration & dosage.pharmacology
Urination.drug effects
Water-Electrolyte Balance.drug effects
Appears in Collections:Journal articles

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