Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13243
Title: Efficacy of 12 months' misoprostol as prophylaxis against NSAID-induced gastric ulcers. A placebo-controlled trial.
Austin Authors: Elliott, S L;Yeomans, Neville D ;Buchanan, Russell R C ;Smallwood, R A
Affiliation: University of Melbourne Department of Medicine, Austin Repatriation Hospital, Australia
Issue Date: 16-May-1994
Publication information: Scandinavian Journal of Rheumatology; 23(4): 171-6
Abstract: We performed a 12-month, double-blind, randomised, placebo-controlled study to determine the long term effect of misoprostol (600-800 micrograms/d) in the prevention of gastric ulcers and gastroduodenal erosions in 83 arthritis patients on chronic NSAID therapy. Patients underwent endoscopy at 0, 3, 6 and 12 months. At the initial endoscopy, 12 patients had an ulcer (11 gastric), which was healed prior to randomization. Seventy eligible patients reached the 3 month endoscopy. Four (12.5%) of the 32 patients given misoprostol developed a gastric ulcer compared with 11 (28.9%) of the 38 on placebo (p < 0.05, life-table analysis). Six of the 11 patients with an initial gastric ulcer developed a further gastric ulcer, compared to 9 of 58 patients without an initial ulcer (p < 0.05). We conclude that misoprostol decreases the cumulative development of NSAID-induced gastric ulcers. Patients with a previous NSAID-ulcer have a higher risk of further ulceration.
Gov't Doc #: 8091141
URI: https://ahro.austin.org.au/austinjspui/handle/1/13243
Journal: Scandinavian journal of rheumatology
URL: https://pubmed.ncbi.nlm.nih.gov/8091141
Type: Journal Article
Subjects: Administration, Oral
Aged
Anti-Inflammatory Agents, Non-Steroidal.adverse effects
Arthritis.drug therapy
Double-Blind Method
Female
Humans
Male
Middle Aged
Misoprostol.administration & dosage.adverse effects
Stomach Ulcer.chemically induced.pathology.prevention & control
Time Factors
Treatment Outcome
Appears in Collections:Journal articles

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