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Title: Reduced femoral neck bone density in the daughters of women with hip fractures: the role of low peak bone density in the pathogenesis of osteoporosis.
Austin Authors: Seeman, Ego ;Tsalamandris, Con;Formica, C;Hopper, John L;McKay, J
Affiliation: Department of Medicine, Austin Hospital Faculty of Medicine, Melbourne, Victoria, Australia
Issue Date: 1-May-1994
Publication information: Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research; 9(5): 739-43
Abstract: Low bone density in women with hip fractures ("senile" osteoporosis) may be due to excessive bone loss or low peak bone density. If excessive bone loss is responsible, then no reduction in bone density is expected in their daughters. If low peak bone density is responsible, then bone density should also be reduced in their daughters because genetic and family environmental factors influence the variability in bone density. Bone density was measured using dual-photon absorptiometry and expressed as a standardized deviation or Z score relative to 697 controls, adjusting for age, height, weight, and menopausal status. In 74 women with hip fractures, the Z score (mean +/- SEM) was -0.52 +/- 0.14 (P < 0.001) at the femoral neck, -1.04 +/- 0.17 (P < 0.001) at the femoral shaft, and -0.43 +/- 0.10 (P < 0.001) at the lumbar spine. In their 41 daughters, the Z score was -0.40 +/- 0.17 (P < 0.05) at the femoral neck, -0.41 +/- 0.19 (P < 0.001) at the femoral shaft, and 0.23 +/- 0.13 (NS) at the lumbar spine. We conclude that daughters of women with hip fractures are likely to be at increased risk for hip fractures themselves because they have reduced femoral neck bone density. Femoral neck fractures may not be entirely attributable to trauma; reduced bone density is likely to contribute and may be caused by the attainment of a lower peak femoral neck bone density.
Gov't Doc #: 8053404
DOI: 10.1002/jbmr.5650090520
Type: Journal Article
Subjects: Absorptiometry, Photon
Bone Density.physiology
Femur Neck.physiology
Hip Fractures.etiology
Middle Aged
Osteoporosis, Postmenopausal.etiology
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