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Title: Haemodynamic, renal and hormonal responses to enalkiren in four patients with post-surgical oliguria.
Austin Authors: Jackson, B ;Liu, G;Perich, R B;Paxton, D;McNicols, L;Gutteridge, Geoffrey A;Johnston, Colin I
Affiliation: Medicine (University of Melbourne)
Issue Date: 1-Feb-1994
Publication information: Clinical and Experimental Pharmacology & Physiology; 21(2): 163-6
Abstract: 1. The haemodynamic and hormonal responses of four patients with acute post-surgical oliguria (urine output < 0.5 mL/kg per h) were measured in response to the renin inhibitor enalkiren. Enalkiren was infused at 0.01 up to 0.1 mg/kg per h for up to 4 h. 2. Enalkiren infusion was associated with a progressive fall in blood pressure, clinically significant in three of the four patients. Systemic vascular resistance fell in proportion to blood pressure fall. Cardiac output and pulse rate remained unchanged. Effective renal plasma flow rose in all four cases (236 +/- 19 to 327 +/- 38). There was no change in urine flow rate, or urinary sodium excretion. 3. Plasma renin activity (ng angiotensin I/mL per h) fell from 1.9 +/- 0.5 to 0.02 +/- 0.01 (P < 0.04), plasma angiotensin II (pg/mL) fell from 104 +/- 93 to 7.7 +/- 1.5, and plasma aldosterone (ng/dL) fell from 32 +/- 8 to 21 +/- 9 (P = 0.03) at the highest infusion dose. 4. Enalkiren inhibited plasma renin activity with reduced plasma angiotensin II and aldosterone concentrations. This was associated with vasodilation, reduced blood pressure and maintained cardiac output. There was no beneficial effect on renal function in these patients with post-surgical oliguria.
Journal: Clinical and Experimental Pharmacology & Physiology
Type: Journal Article
Subjects: Aldosterone.blood
Angiotensin II.blood
Blood Pressure.drug effects
Cardiac Output.drug effects
Coronary Artery Bypass
Dipeptides.administration & dosage.adverse effects.therapeutic use
Hemodynamics.drug effects
Kidney.drug effects
Oliguria.drug therapy.physiopathology
Postoperative Complications.drug therapy.physiopathology
Pulse.drug effects
Renal Plasma Flow, Effective.drug effects
Renin.antagonists & inhibitors.blood
Renin-Angiotensin System.drug effects
Vascular Resistance.drug effects
Appears in Collections:Journal articles

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