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Title: Lymphoproliferative disease of donor origin arising in patients after orthotopic liver transplantation.
Austin Authors: Armes, J E;Angus, Peter W ;Southey, M C;Battaglia, S E;Ross, B C;Jones, Robert M ;Venter, D J
Affiliation: Department of Anatomical Pathology, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Nov-1994
Publication information: Cancer; 74(9): 2436-41
Abstract: Lymphoproliferative disease is a well recognized complication of organ transplantation and in many cases is associated with Epstein-Barr virus (EBV) infection. It is widely though that posttransplantation lymphoproliferative disease (PTLPD) arises from recipient lymphoid cells. However, solid organ allografts are likely to include donor lymphoid tissue around or within the transplanted organ. Therefore, it is possible that transplanted donor lymphocytes may proliferate to form PTLPD:The genetic origin of tumor cells was determined by microsatellite DNA fingerprinting using the polymerase chain reaction (PCR). Their EBV association and clonality were established by PCR amplification of DNA extracted from formalin fixed, paraffin embedded tissue using primers to conserved regions of the EBV genome and the immunoglobulin heavy chain gene, respectively.The authors have demonstrated two cases of lymphoproliferative disease that were derived from donor lymphocytes in orthotopic liver transplant recipients. In both cases, the proliferating cells were EBV DNA positive. Furthermore, the PTLPD was restricted to allograft tissue around the porta hepatis. However, the two cases differed in their clonal properties and response to treatment: one case was oligoclonal and regressed after antiviral therapy and a modest reduction of immunosuppression, whereas the other contained two clonal populations and was controlled only after treatment with antineoplastic chemotherapy.This study has demonstrated two cases of PTLPD that were derived from donor lymphoid tissue. Although both cases were associated with EBV and remained localized to allograft tissue, their clonality and response to therapy differed.
Gov't Doc #: 7922997
Type: Journal Article
Subjects: Adult
Base Sequence
DNA, Viral.genetics
Gene Rearrangement
Herpesviridae Infections.etiology.immunology.pathology
Herpesvirus 4, Human.genetics.immunology
Immunoglobulin Heavy Chains.genetics
Liver Diseases.etiology.immunology.pathology
Liver Transplantation.adverse effects.immunology.pathology
Lymphoproliferative Disorders.etiology.pathology.virology
Middle Aged
Molecular Sequence Data
Polymerase Chain Reaction
Tissue Donors
Tumor Virus Infections.etiology.immunology.pathology
Appears in Collections:Journal articles

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