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Title: Ictal postictal and interictal single-photon emission tomography in the lateralization of temporal lobe epilepsy.
Austin Authors: Newton, Mark R;Berkovic, Samuel F ;Austin, M C;Rowe, Christopher C ;McKay, W J;Bladin, Peter F 
Affiliation: Department of Neurology, Austin Hospital, Melbourne, Victoria, Australia
Issue Date: 1-Oct-1994
Publication information: European Journal of Nuclear Medicine; 21(10): 1067-71
Abstract: Single-photon emission tomography (SPET) using radioligands that are fixed on first pass through the cerebral circulation shows distinctive and rapidly changing blood flow patterns accompanying temporal lobe seizures. We sought to determine the optimal time to perform SPET studies for clinical seizure lateralization in temporal lobe epilepsy. Interictal, ictal and postictal SPET scans of 73 consecutively studied patients with unilateral temporal lobe epilepsy were read by three blinded observers to assess the accuracy of lateralization in each condition. The blinded observers correctly identified the side of focus in 97% of ictal studies, 72% of postictal studies and 50% of interictal studies. No incorrect scores were made in the ictal studies, whilst 5% of postictal and 12% of interictal studies were lateralized to the wrong side. Inter-observer agreement was best with the ictal studies. The dramatic perfusion changes of ictal SPET provide consistent, reliable and easily interpretable information that is superior to that provided by interictal and postictal studies. Injection of ligand during seizures is therefore the method of choice for SPET to aid the non-invasive lateralization of temporal seizure foci.
Gov't Doc #: 7828616
Journal: European journal of nuclear medicine
Type: Journal Article
Subjects: Adult
Cerebrovascular Circulation.physiology
Epilepsy, Temporal Lobe.radionuclide imaging
Observer Variation
Organotechnetium Compounds.diagnostic use
Oximes.diagnostic use
Technetium Tc 99m Exametazime
Temporal Lobe.radionuclide imaging
Time Factors
Tomography, Emission-Computed, Single-Photon.methods
Appears in Collections:Journal articles

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