Please use this identifier to cite or link to this item:
Title: Short term effects of pravastatin on blood pressure in hypercholesterolaemic hypertensive patients.
Austin Authors: O'Callaghan, Christopher J ;Krum, Henry;Conway, Elizabeth L;Lam, W;Skiba, M A;Howes, L G;Louis, William J 
Affiliation: Hypertension Services, Austin Hospital, Heidelberg, Australia
Issue Date: 1-Nov-1994
Publication information: Blood Pressure; 3(6): 404-6
Abstract: In this study, which was primarily designed to determine the lipid-lowering efficacy of pravastatin in the setting of background antihypertensive therapy with ACE inhibitors and calcium antagonists, we took the opportunity to examine whether pravastatin interacts with antihypertensive therapy to produce additional falls in blood pressure. This may help clarify the mechanism of action of pravastatin's rapid beneficial effects on cardiovascular morbidity. We treated 25 hypertensive hypercholesterolaemic patients with 12 weeks of either pravastatin or placebo in this double blind, placebo controlled parallel group study. Placebo treatment did not alter plasma lipids, whereas 12 weeks' treatment with pravastatin reduced total cholesterol by 27% (from 7.1 +/- 0.27 to 5.2 +/- 0.18, p < 0.001 compared with placebo) and low density lipoprotein cholesterol by 35% (from 4.9 +/- 0.36 to 3.2 +/- 0.17, p < 0.001). There were no changes in systolic or diastolic blood pressure either following 12 weeks' treatment or 3 weeks' withdrawal of pravastatin. Thus, pravastatin remains efficacious as a lipid lowering agent in the presence of antihypertensive therapy but does not enhance the blood pressure lowering action of these drugs. Therefore it is unlikely that blood pressure reduction is the mechanism by which pravastatin mediates its reported short term effects on cardiovascular morbidity.
Gov't Doc #: 7704289
Journal: Blood pressure
Type: Journal Article
Subjects: Blood Pressure.drug effects
Captopril.pharmacology.therapeutic use
Cholesterol, LDL.blood
Combined Modality Therapy
Double-Blind Method
Drug Interactions
Felodipine.pharmacology.therapeutic use
Humans therapy.drug therapy.physiopathology
Hypertension.blood.complications.drug therapy.physiopathology
Middle Aged
Pravastatin.pharmacology.therapeutic use
Appears in Collections:Journal articles

Show full item record

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.