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Title: Attenuation of genetic hypertension after short-term vasopressin V1A receptor antagonism.
Austin Authors: Burrell, Louise M ;Phillips, P A;Risvanis, John;Aldred, K L;Hutchins, A M;Johnston, Colin I
Affiliation: Medicine (University of Melbourne)
Issue Date: 1-Nov-1995
Publication information: Hypertension; 26(5): 828-34
Abstract: Abnormalities of the vasopressin system are found in genetic hypertension. This study compares the delayed effects of a brief period of vasopressin V1A receptor blockade and angiotensin-converting enzyme inhibition in young female and male spontaneously hypertensive rats (SHR) on the development of hypertension in adult life. In a separate study, the role of vasopressin in the maintenance of blood pressure in adult SHR was assessed. Young SHR received either the nonpeptide vasopressin V1A receptor antagonist OPC-21268, the angiotensin-converting enzyme inhibitor ramipril, or vehicle from 6 to 10 weeks of age. During the treatment period, OPC-21268 and ramipril reduced systolic blood pressure compared with control SHR (P < .001). Blood pressure in male SHR 7 weeks after treatment withdrawal was 178 +/- 1 mm Hg in ramipril-treated, 184 +/- 1 mm Hg in OPC-21268-treated, and 200 +/- 2 mm Hg in control SHR (P < .001). Similar results were seen in female SHR, although both OPC-21268 and ramipril were less effective antihypertensive agents in female compared with male SHR. The sustained attenuation in blood pressure was not associated with significant cardiovascular structural changes (left ventricular-to-body weight ratio, renal weight-to-body weight ratio, mesenteric resistance artery media-to-lumen ratio). Results of vasopressin V1A receptor binding kinetics and plasma renin or aldosterone concentrations did not suggest a lasting effect of OPC-21268 on the vasopressin system or of ramipril on the renin-angiotensin system following treatment withdrawal.(ABSTRACT TRUNCATED AT 250 WORDS)
Journal: Hypertension
Type: Journal Article
Subjects: Aging
Angiotensin-Converting Enzyme Inhibitors.therapeutic use
Antidiuretic Hormone Receptor Antagonists
Blood Pressure
Body Weight
Hypertension.genetics.physiopathology.prevention & control
Piperidines.therapeutic use
Quinolones.therapeutic use
Ramipril.therapeutic use
Rats, Inbred SHR
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