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Title: Fetal metabolism and placental transfer of vasoactive intestinal peptide in sheep.
Austin Authors: Shulkes, Arthur;Henderson, T;Hardy, Kenneth John
Affiliation: Department of Surgery, University of Melbourne, Austin Hospital, Victoria, Australia
Issue Date: 1-Aug-1987
Publication information: Biology of Reproduction; 37(1): 1-5
Abstract: Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid putative neurotransmitter that may have a role in the regulation of myometrial blood flow and uterine contractility. The chronically cannulated fetal sheep preparation was used to examine the fetal clearance and placental transfer of VIP. Metabolic Clearance Rate (MCR) and placental transfer of VIP were measured by alternate steady-state infusion of VIP into the mother and fetus. Plasma concentrations of VIP were measured by radioimmunoassay. MCR was similar in the pregnant (45 +/- 10 ml/kg/min) and nonpregnant ewes (35 +/- 5 ml/kg/min). However, compared to both pregnant and nonpregnant ewes, fetal MCR was significantly increased at 77 +/- 15 ml/kg/min, indicating highly developed clearance mechanisms in the fetus. VIP did not cross the placenta in either direction. Both the placenta and fetal liver metabolized VIP and contributed to the elevated fetal clearance of VIP. The results show that VIP in fetal tissue is unlikely to influence maternal uterine activity with any VIP-mediated effects emanating from maternal and/or placental sources.
Gov't Doc #: 3651537
Type: Journal Article
Subjects: Animals
Maternal-Fetal Exchange
Metabolic Clearance Rate
Vasoactive Intestinal Peptide.pharmacokinetics
Appears in Collections:Journal articles

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