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Title: | Comparative neuroanatomy of angiotensin II receptor localization in the mammalian hypothalamus. | Austin Authors: | Allen, A M;McKinley, M J;Mendelsohn, Frederick AO | Affiliation: | University of Melbourne Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 1-Feb-1988 | Publication information: | Clinical and Experimental Pharmacology & Physiology; 15(2): 137-45 | Abstract: | 1. The distribution of angiotensin II (AII) receptor binding sites in the hypothalamus of rat, rabbit, sheep and human was determined by in vitro autoradiography using 125I-[Sar1,Ile8]-AII as radioligand. 2. High receptor binding levels were observed in the continuum of tissue comprising the anterior wall of the third ventricle, including the subfornical organ, the median pre-optic nucleus and the organum vasculosum of the lamina terminalis. 3. High levels of binding sites were also found in the paraventricular and supra-optic nuclei, the median eminence and the arcuate nucleus. 4. These findings demonstrate sites in the hypothalamus of rat, rabbit, sheep and human where AII could exert its known actions on fluid and electrolyte balance, pituitary hormone release and cardiovascular function. | Gov't Doc #: | 3271605 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12956 | Journal: | Clinical and Experimental Pharmacology & Physiology | URL: | https://pubmed.ncbi.nlm.nih.gov/3271605 | Type: | Journal Article | Subjects: | Aged Animals Autoradiography Female Humans Hypothalamus.anatomy & histology.metabolism In Vitro Techniques Iodine Radioisotopes.diagnostic use Male Rabbits Rats Rats, Inbred Strains Receptors, Angiotensin.drug effects.metabolism Saralasin.pharmacology Sheep Species Specificity |
Appears in Collections: | Journal articles |
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