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Title: Effects of continuous infusions (10 days) and cessation of infusions of clonidine and rilmenidine (S 3341) on cardiovascular and behavioral parameters of spontaneously hypertensive rats.
Austin Authors: Jarrott, B;Lewis, S J;Doyle, A E;Louis, William J 
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 24-Feb-1988
Publication information: The American Journal of Cardiology; 61(7): 39D-44D
Abstract: Clonidine is a centrally acting antihypertensive drug that acts in vivo at both alpha 1- and alpha 2-adrenoceptor sites, whereas rilmenidine (S 3341) is more selective for alpha 2 adrenoceptors. The present study compared the effects of continuous 10-day infusions of clonidine (5 micrograms/kg/hour) with those of rilmenidine (100 micrograms/kg/hour) on various cardiovascular and behavioral parameters in the spontaneously hypertensive rat. The changes in these parameters after cessation of the infusions were also compared. At these rates of infusion, clonidine and rilmenidine produced quantitatively similar reductions in mean arterial pressure (MAP), lability of MAP and cardiovascular responsiveness during normal behaviors such as eating and grooming. Neither drug infusion affected heart rate. The cessation of the clonidine infusion resulted in a "withdrawal" syndrome characterized by prominent rapid eye movement-sleep rebound, and cardiovascular and behavioral disturbances including an increased lability of MAP, exaggerated cardiovascular responses during normal behaviors, tachycardia, and an "opiate abstinence-like" syndrome including head and body shakes. Cessation of rilmenidine infusion resulted in somewhat similar cardiovascular and behavioral disturbances, but unlike clonidine there was a return to normal rapid eye movement sleep without rebound.
Gov't Doc #: 2894156
Type: Journal Article
Subjects: Adrenergic alpha-Agonists.pharmacology
Behavior, Animal.drug effects
Blood Pressure.drug effects
Clonidine.administration & dosage.pharmacology
Heart Rate.drug effects
Infusion Pumps
Oxazoles.administration & dosage.pharmacology
Rats, Inbred SHR
Sleep, REM.drug effects
Time Factors
Appears in Collections:Journal articles

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