Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12882
Title: Sites of actions of alpha 2 agonists in the brain and periphery.
Austin Authors: Louis, William J ;Jarrott, B;Conway, Elizabeth L
Affiliation: Clinical Pharmacology and Therapeutics Unit, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 24-Feb-1988
Publication information: The American Journal of Cardiology; 61(7): 15D-17D
Abstract: Alpha 2 agonists including rilmenidine, clonidine and alpha methylnoradrenaline all seem to have a predominantly central action in lowering blood pressure. Studies using the peripheral decarboxylase inhibitor alpha-methyldopa hydrazine in both experimental animals and humans support the predominant central action of the active metabolite of methyldopa, alpha methylnoradrenaline. Comparative studies on the antihypertensive potency of selective alpha 2 agonists like rilmenidine, guanfacine, clonidine and lofexidine suggest that the relative ability to bind to alpha 1 and alpha 2 adrenoceptors is not critical but the ability to enter the central nervous system is essential for antihypertensive efficacy.
Gov't Doc #: 2894151
URI: https://ahro.austin.org.au/austinjspui/handle/1/12882
Journal: The American journal of cardiology
URL: https://pubmed.ncbi.nlm.nih.gov/2894151
Type: Journal Article
Subjects: Adrenergic alpha-Agonists.pharmacokinetics.pharmacology
Animals
Binding Sites
Blood Pressure.drug effects
Brain.drug effects.metabolism
Carbidopa.pharmacokinetics.pharmacology
Clonidine.pharmacokinetics.pharmacology
Decarboxylation
Methyldopa.pharmacokinetics.pharmacology
Neurotransmitter Agents.metabolism
Radioligand Assay
Receptors, Adrenergic, alpha.metabolism.physiology
Vasoconstriction.drug effects
Appears in Collections:Journal articles

Show full item record

Page view(s)

18
checked on Dec 1, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.