Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12863
Title: Lack of cross sensitivity between captopril and enalapril.
Austin Authors: Jackson, B ;Maher, D;Matthews, P G;McGrath, B P;Johnston, Colin I
Affiliation: Austin Hospital, University of Melbourne, Department of Medicine, Heidelberg, Australia
Issue Date: 1-Feb-1988
Publication information: Australian and New Zealand Journal of Medicine; 18(1): 21-7
Abstract: Oral inhibitors of angiotensin converting enzyme (ACE) now have an established place in the treatment of hypertension and heart failure. Captopril, the first of these agents, was initially used in high doses and was associated with adverse effects including proteinuria, skin rash and taste disturbance. We report 11 patients who developed side effects during captopril therapy (proteinuria two, rash four, taste disturbance four and taste disturbance with rash one) who were subsequently treated with enalapril, a second generation angiotensin converting enzyme inhibitor. Proteinuria did not recur in either patient, skin rash resolved in all five cases and taste disturbance resolved in four of five during enalapril therapy. We conclude that the side effects of proteinuria, skin rash and taste disturbance are consequences of captopril idiosyncrasy rather than inhibition of the angiotensin converting enzyme. The reported incidence of these side effects with the current recommended dosage of captopril is low.
Gov't Doc #: 2840055
URI: http://ahro.austin.org.au/austinjspui/handle/1/12863
URL: https://pubmed.ncbi.nlm.nih.gov/2840055
Type: Journal Article
Subjects: Captopril.adverse effects
Drug Eruptions.etiology
Enalapril.therapeutic use
Female
Heart Failure.drug therapy
Humans
Hypertension.drug therapy
Hypertension, Renovascular.drug therapy
Male
Middle Aged
Proteinuria.chemically induced
Taste Disorders.chemically induced
Appears in Collections:Journal articles

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