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Title: Monoamine oxidase, monoamine oxidase inhibitors, and panic disorder.
Austin Authors: Norman, Trevor R ;Burrows, Graham D
Affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 16-May-1989
Publication information: Journal of Neural Transmission. Supplementum; 28(): 53-63
Abstract: Monoamine oxidase inhibitors are effective in the treatment of panic attacks. Phenelzine has been used most often with good effect and is regarded by some as the treatment of first choice for panic disorders. Nevertheless the potential dangers of the use of non-specific MAOIs are well recognised and there is a need for safer drugs. The efficacy of specific MAO inhibitors such as moclobemide (MAO-A) and deprenyl (MAO-B) are yet to be investigated. The activity of the enzyme MAO in blood platelet (MAO-B) has been extensively studied. A review of early findings of elevated MAO activity suggests a number of reasons why the data should be interpreted with caution. Recent studies do not support the earlier findings and suggest no difference in platelet MAO activity between patients and controls. Similarly studies of the endogenous MAO inhibitor, tribulin, suggest that the output in panic disorder patients is similar to that of controls. Studies of the effectiveness of specific MAOIs in panic attacks are warranted as are further studies of the biochemical aetiology.
Gov't Doc #: 2677243
Type: Journal Article
Subjects: Fear
Mental Disorders.drug therapy.enzymology
Monoamine Oxidase.metabolism
Monoamine Oxidase Inhibitors.therapeutic use
Appears in Collections:Journal articles

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