Austin Health

Title
Streptozotocin-induced diabetes reduces the density of [125I]-endothelin-binding sites in rat cardiac membranes.
Publication Date
1989-08-01
Author(s)
Nayler, W G
Liu, J J
Panagiotopoulos, Sianna
Casley, David J
Type of document
Journal Article
OrcId
0000-0002-0845-0001
Abstract
The effect of acute, streptozotocin-induced diabetes on the affinity (KD), density (Bmax) and selectivity of specific, high affinity binding sites for [125I]-endothelin [( 125I]-ET) in rat cardiac membrane fragments was determined. Three days after a single i.v. bolus dose of streptozotocin (60 mg kg-1), the density of [125I]ET binding sites was reduced (P less than 0.01) without changes in affinity or selectivity.
Link
link
Citation
British Journal of Pharmacology; 97(4): 993-5
Jornal Title
British journal of pharmacology

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