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Title: A short term open clinical trial of clobazam in the treatment of patients with panic attacks.
Austin Authors: Judd, F K;Burrows, Graham D;Marriott, P F;Norman, Trevor R 
Affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Oct-1989
Publication information: International Clinical Psychopharmacology; 4(4): 285-93
Abstract: Clobazam, a 1-5 benzodiazepine with anxiolytic properties, was evaluated in the treatment of patients with DSM-III panic disorder or agoraphobia with panic attacks. In this open clinical trial, 10 of the 15 patients completed 8 weeks of treatment. Six of the 10 completers (60%) were responders (75% reduction in the number of panic attacks from baseline) at the end of 8 weeks. Of the responders so defined, 5 of the 6 were panic free. At the end of week 8 the average dose for the responders to medication was 50 +/- 17 (S.D.) mg per day. Clobazam was well tolerated at the doses used with the few side-effects recorded as mild to moderate. The study suggests that further placebo-controlled studies are warranted to evaluate clobazam's potential antipanic effect.
Gov't Doc #: 2575098
Type: Journal Article
Subjects: Adolescent
Anti-Anxiety Agents.adverse effects.therapeutic use
Anxiety Disorders.drug therapy
Benzodiazepinones.adverse effects.therapeutic use
Clinical Trials as Topic
Random Allocation
Time Factors
Appears in Collections:Journal articles

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