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Title: Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer.
Austin Authors: Pereira, Lloyd;Mariadason, John M ;Hannan, Ross D;Dhillon, Amardeep S
Affiliation: Olivia Newton-John Cancer Research Institute
Research Division, Peter MacCallum Cancer Centre , Melbourne, VIC , Australia
Sir Peter MacCallum Department of Oncology, The University of Melbourne , Melbourne, VIC , Australia
Department of Pathology, The University of Melbourne , Melbourne, VIC , Australia
Department of Biochemistry and Molecular Biology, The University of Melbourne , Melbourne, VIC , Australia
Issue Date: 2-Feb-2015
Publication information: Frontiers in Oncology 2015; 5: 13
Abstract: Colorectal cancer (CRC) is a genetically heterogeneous disease that develops and progresses through several distinct pathways characterized by genomic instability. In recent years, it has emerged that inherent plasticity in some populations of CRC cells can contribute to heterogeneity in differentiation state, metastatic potential, therapeutic response, and disease relapse. Such plasticity is thought to arise through interactions between aberrant signaling events, including persistent activation of the APC/β-catenin and KRAS/BRAF/ERK pathways, and the tumor microenvironment. Here, we highlight key concepts and evidence relating to the role of epithelial-mesenchymal plasticity as a driver of CRC progression and stratification of the disease into distinct molecular and clinicopathological subsets.
DOI: 10.3389/fonc.2015.00013
Journal: Frontiers in oncology
Type: Journal Article
Subjects: CRC
cancer stem cell
epithelial–mesenchymal transition
tumor progression
Appears in Collections:Journal articles

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