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Title: Comorbidities Frequency in Takotsubo Syndrome: An International Collaborative Systematic Review Including 1109 Patients.
Austin Authors: Pelliccia, Francesco;Parodi, Guido;Greco, Cesare;Antoniucci, David;Brenner, Roman;Bossone, Eduardo;Cacciotti, Luca;Capucci, Alessandro;Citro, Rodolfo;Delmas, Clément;Guerra, Federico;Ionescu, Costin N;Lairez, Olivier;Larrauri-Reyes, Maiteder;Lee, Pil Hyung;Mansencal, Nicolas;Marazzi, Giuseppe;Mihos, Christos G;Morel, Olivier;Nef, Holger M;Nunez Gil, Ivan J;Passaseo, Ilaria;Pineda, Andres M;Rosano, Giuseppe;Santana, Orlando;Schneck, Franziska;Song, Bong Gun;Song, Jae-Kwan;Teh, Andrew W ;Ungprasert, Patompong;Valbusa, Alberto;Wahl, Andreas;Yoshida, Tetsuro;Gaudio, Carlo;Kaski, Juan Carlos
Affiliation: Department of Cardiology, Austin Hospital, Victoria, Australia
Cardiology Department, Eastern Health Clinical School, Monash University, Victoria, Australia
L'Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Pisana, Rome, Italy; Cardiovascular and Cell Sciences Research Institute, St. George's, University of London, London, UK
Cardiovascular and Cell Sciences Research Institute, St. George's, University of London, London, UK
Department of Cardiovascular Sciences, Sapienza University, Rome, Italy
Department of Cardiovascular Sciences, Sapienza University, Rome, Italy.
Department of Heart and Vessels, Careggi Hospital, Florence, Italy.
Department of Cardiology, Kantonsspital, CH-St.Gallen, Switzerland.
Department of Cardiology, University Hospital San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.
Department of Cardiology, Rangueil University Hospital, Toulouse, France.
Cardiology and Arrhythmology Clinic, Marche Polytechnic University, Ancona, Italy.
Cardiovascular Section, Yale University, New Haven, Conn.
Hôpital Ambroise Paré, Service de Cardiologie, Centre de Référence des Maladies Cardiaques Héréditaires, Université de Versailles Saint-Quentin, Boulogne, France.
L'Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Pisana, Rome, Italy.
Pôle d'activité medico-chirurgicale Cardiovasculaire, Strasbourg, France.
Cardiovascular Institute, Hospital Clínico San Carlos, Madrid, Spain.
Cardiology Unit, Ospedale Vannini, Rome, Italy.
Cardiology Department, Mount Sinai Medical Center, Miami Beach, Fla.
Department of Cardiology and Angiology, University of Giessen, Giessen, Germany.
Cardiac and Vascular Center, Konkuk University Hospital, Seoul, South Korea.
Asan Medical Center Heart Institute, University of Ulsan College of Medicine, Seoul, South Korea.
Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
IRCCS Azienza Ospedaliera, Universitaria San Martino-IST, Genova, Italy.
Cardiology, University Hospital, Bern, Switzerland.
Department of Cardiovascular of Medicine, Onga Nakama Medical Association, Onga Hospital, Onga, Japan.
Issue Date: 4-Feb-2015
Publication information: The American Journal of Medicine 2015; 128(6): 654.e11-9
Abstract: To identify predisposing factors that can result in the onset of takotsubo syndrome, we performed an international, collaborative systematic review focusing on clinical characteristics and comorbidities of patients with takotsubo syndrome.We searched and reviewed cited references up to August 2013 to identify relevant studies. Corresponding authors of selected studies were contacted and asked to provide additional quantitative details. Data from each study were extracted by 2 independent reviewers. The cumulative prevalence of presenting features and comorbidities was assessed. Nineteen studies whose authors sent the requested information were included in the systematic review, with a total of 1109 patients (951 women; mean age, 59-76 years). Evaluation of risk factors showed that obesity was present in 17% of patients (range, 2%-48%), hypertension in 54% (range, 27%-83%), dyslipidemia in 32% (range, 7%-59%), diabetes in 17% (range, 4%-34%), and smoking in 22% (range, 6%-49%). Emotional stressors preceded takotsubo syndrome in 39% of patients and physical stressors in 35%. The most common comorbidities were psychological disorders (24%; range, 0-49%), pulmonary diseases (15%; range, 0-22%), and malignancies (10%; range, 4%-29%). Other common associated disorders were neurologic diseases (7%; range, 0-22%), chronic kidney disease (7%; range, 2%-27%), and thyroid diseases (6%; range, 0-37%).Patients with takotsubo syndrome have a relevant prevalence of cardiovascular risk factors and associated comorbidities. Such of associations needs to be evaluated in further studies.
Gov't Doc #: 25660245
DOI: 10.1016/j.amjmed.2015.01.016
Journal: The American journal of medicine
Type: Journal Article
Subjects: Acute left ventricular dysfunction
Apical ballooning syndrome
Takotsubo cardiomyopathy
Takotsubo syndrome
Appears in Collections:Journal articles

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