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Title: Effects of epithelial to mesenchymal transition on T cell targeting of melanoma cells.
Austin Authors: Woods, Katherine;Pasam, Anupama;Jayachandran, Aparna;Andrews, Miles C;Cebon, Jonathan S 
Affiliation: School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia
Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia
Cancer Immunobiology Laboratory,Ludwig Institute for Cancer Research, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 17-Dec-2014
Publication information: Frontiers in Oncology 2014; 4(): 367
Abstract: Melanoma cells can switch phenotype in a manner similar to epithelial to mesenchymal transition (EMT). In this perspective article, we address the effects of such phenotype switching on T cell targeting of tumor cells. During the EMT-like switch in phenotype, a concomitant change in expression of multiple tumor antigens occurs. Melanoma cells undergoing EMT escape from killing by T cells specific for antigens whose expression is downregulated by this process. We discuss melanoma antigens whose expression is influenced by EMT. We assess the effect of changes in the expressed tumor antigen repertoire on T-cell mediated tumor recognition and killing. In addition to escape from T cell immunity via changes in antigen expression, mesenchymal-like melanoma cells are generally more resistant to classical chemotherapy and radiotherapy. However, we demonstrate that when targeting antigens whose expression is unaltered during EMT, the capacity of T cells to kill melanoma cell lines in vitro is not influenced by their phenotype. When considering immune therapies such as cancer vaccination, these data suggest escape from T cell killing due to phenotype switching in melanoma could potentially be avoided by careful selection of target antigen.
Gov't Doc #: 25566505
DOI: 10.3389/fonc.2014.00367
Journal: Frontiers in oncology
Type: Journal Article
Subjects: T cell killing
cancer testis antigens
epithelial–mesenchymal transition
tumor antigens
Appears in Collections:Journal articles

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