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Title: Cyclosporine increases endothelin-1 binding site density in cardiac cell membranes.
Austin Authors: Nayler, W G;Gu, X H;Casley, David J;Panagiotopoulos, Sianna ;Liu, J;Mottram, P L
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Victoria, Australia
Issue Date: 29-Sep-1989
Publication information: Biochemical and Biophysical Research Communications; 163(3): 1270-4
Abstract: When used in high concentrations, the immunosuppressive agent cyclosporine A has toxic side effects, including cardiac fibrosis and calcification. Cyclosporine-treated mice were used to investigate whether a cyclosporine dose regime which produces cardiac fibrosis and calcification alters the density of the specific binding sites for the endothelial-derived vasoconstrictor polypeptide, endothelin-1. After twenty-one days of treatment the endothelin-1 binding site density in cardiac cell membranes was increased, without any change in selectivity. This increase in endothelin-1 binding site density could contribute to the cytotoxic effects of cyclosporine.
Gov't Doc #: 2551284
ORCID: 0000-0002-0845-0001
Type: Journal Article
Subjects: Animals
Cell Membrane.metabolism
Endothelium, Vascular
Heart.drug effects
Mice, Inbred CBA
Receptors, Cell Surface.drug effects.metabolism
Receptors, Endothelin
Reference Values
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