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|Title:||Cyclosporine increases endothelin-1 binding site density in cardiac cell membranes.||Austin Authors:||Nayler, W G;Gu, X H;Casley, David J;Panagiotopoulos, Sianna ;Liu, J;Mottram, P L||Affiliation:||Department of Medicine, University of Melbourne, Austin Hospital, Victoria, Australia||Issue Date:||29-Sep-1989||Publication information:||Biochemical and Biophysical Research Communications; 163(3): 1270-4||Abstract:||When used in high concentrations, the immunosuppressive agent cyclosporine A has toxic side effects, including cardiac fibrosis and calcification. Cyclosporine-treated mice were used to investigate whether a cyclosporine dose regime which produces cardiac fibrosis and calcification alters the density of the specific binding sites for the endothelial-derived vasoconstrictor polypeptide, endothelin-1. After twenty-one days of treatment the endothelin-1 binding site density in cardiac cell membranes was increased, without any change in selectivity. This increase in endothelin-1 binding site density could contribute to the cytotoxic effects of cyclosporine.||Gov't Doc #:||2551284||URI:||http://ahro.austin.org.au/austinjspui/handle/1/12537||ORCID:||0000-0002-0845-0001||URL:||https://pubmed.ncbi.nlm.nih.gov/2551284||Type:||Journal Article||Subjects:||Animals
Mice, Inbred CBA
Receptors, Cell Surface.drug effects.metabolism
|Appears in Collections:||Journal articles|
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