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Title: Tau imaging: early progress and future directions.
Austin Authors: Villemagne, Victor L ;Fodero-Tavoletti, Michelle T;Masters, Colin L ;Rowe, Christopher C 
Affiliation: Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
The Florey Institute, The University of Melbourne, Victoria, Australia
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 1-Jan-2015
Publication information: The Lancet. Neurology; 14(1): 114-24
Abstract: Use of selective in-vivo tau imaging will enable improved understanding of tau aggregation in the brain, facilitating research into causes, diagnosis, and treatment of major tauopathies such as Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, chronic traumatic encephalopathy, and some variants of frontotemporal lobar degeneration. Neuropathological studies of Alzheimer's disease show a strong association between tau deposits, decreased cognitive function, and neurodegenerative changes. Selective tau imaging will allow the in-vivo exploration of such associations and measure the global and regional changes in tau deposits over time. Such imaging studies will comprise non-invasive assessment of the spatial and temporal pattern of tau deposition over time, providing insight into the role tau plays in ageing and helping to establish the relation between cognition, genotype, neurodegeneration, and other biomarkers. Once validated, selective tau imaging might be useful as a diagnostic, prognostic, and progression biomarker, and a surrogate marker for the monitoring of efficacy and patient recruitment for anti-tau therapeutic trials.
DOI: 10.1016/S1474-4422(14)70252-2
Type: Journal Article
Subjects: Biological Markers.metabolism
Brain.metabolism.radionuclide imaging
Neurodegenerative Diseases.diagnosis
Positron-Emission Tomography.methods
tau Proteins.metabolism
Appears in Collections:Journal articles

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