Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12522
Title: Enalapril retards glomerular basement membrane thickening and albuminuria in the diabetic rat.
Austin Authors: Cooper, Mark E;Allen, Terri J;Macmillan, P A;Clarke, B E;Jerums, George ;Doyle, A E
Affiliation: Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-May-1989
Publication information: Diabetologia; 32(5): 326-8
Abstract: This study has evaluated the effects of the angiotensin converting enzyme inhibitor Enalapril on glomerular ultrastructure and albuminuria in normotensive and hypertensive diabetic rats. Streptozotocin-diabetes was induced in Wistar Kyoto and spontaneously hypertensive rats. Enalapril was administered in drinking water in diabetic normotensive, control hypertensive and diabetic hypertensive rats. Enalapril therapy prevented an increase in glomerular basement membrane thickness in diabetic normotensive, control hypertensive and diabetic hypertensive rats without any significant effect on fractional mesangial volume. Enalapril decreased albuminuria in diabetic normotensive, control hypertensive and diabetic hypertensive rats. Thus, enalapril retards the development of glomerular basement membrane thickening and albuminuria in the rat, in the presence or absence of hypertension.
Gov't Doc #: 2546846
URI: http://ahro.austin.org.au/austinjspui/handle/1/12522
URL: https://pubmed.ncbi.nlm.nih.gov/2546846
Type: Journal Article
Subjects: Albuminuria
Animals
Basement Membrane.drug effects.pathology.ultrastructure
Blood Pressure
Diabetes Mellitus, Experimental.drug therapy.pathology
Diabetic Nephropathies.pathology.prevention & control
Enalapril.therapeutic use
Kidney Glomerulus.drug effects.pathology.ultrastructure
Male
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Reference Values
Appears in Collections:Journal articles

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