Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/12507| Title: | The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET. | Austin Authors: | Klunk, William E;Koeppe, Robert A;Price, Julie C;Benzinger, Tammie L;Devous, Michael D;Jagust, William J;Johnson, Keith A;Mathis, Chester A;Minhas, Davneet;Pontecorvo, Michael J;Rowe, Christopher C ;Skovronsky, Daniel M;Mintun, Mark A | Affiliation: | Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA Department of Radiology, University of Michigan, Ann Arbor, MI, USA Department of Neurology, University of Pittsburgh, Pittsburgh. PA, USA Department of Radiology, Massachusetts General Hospital, Boston, MA, USA Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia, Australia Department of Neurology, Massachusetts General Hospital, Boston, MA, USA Departments of Radiology, Pharmacology and Biological Chemistry, and Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA Department of Neurosurgery, Washington University, Saint Louis, MO, USA Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Avid Radiopharmaceuticals, Philadelphia, PA, USA Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA |
Issue Date: | 28-Oct-2014 | Publication information: | Alzheimer's & Dementia : the Journal of the Alzheimer's Association 2014; 11(1): 1-15.e1-4 | Abstract: | Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (≤ 45 years) and typical Alzheimer's disease patients. The units of this scale have been named "Centiloids." Basically, we describe a "standard" method of analyzing PiB PET data and then a method for scaling any "nonstandard" method of PiB PET analysis (or any other tracer) to the Centiloid scale. | Gov't Doc #: | 25443857 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12507 | DOI: | 10.1016/j.jalz.2014.07.003 | Journal: | Alzheimer's & dementia : the journal of the Alzheimer's Association | URL: | https://pubmed.ncbi.nlm.nih.gov/25443857 | Type: | Journal Article | Subjects: | Amyloid imaging Centiloid scale Pittsburgh compound B Positron emission tomography Standardize |
| Appears in Collections: | Journal articles |
Show full item record
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.