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Title: Ramipril reduces albuminuria in diabetic rats fed a high protein diet.
Austin Authors: O'Brien, R C;Cooper, Mark E;Allen, Terri J;Jerums, George 
Affiliation: Department of Medicine, Austin Hospital, University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 1-Aug-1989
Publication information: Clinical and Experimental Pharmacology & Physiology; 16(8): 675-80
Abstract: 1. Streptozotocin diabetes was induced in Wistar-Kyoto rats fed a 50% protein diet. Animals were randomized to receive either the ACE inhibitor ramipril, 1 mg/L in drinking water (n = 7), or no treatment (n = 7) and were studied for 6 months. Blood glucose, body weight and glomerular filtration rate (GFR) were measured at 0, 1, 4, 8 and 16 weeks of diabetes and urinary albumin excretion was measured every 8 weeks. 2. In both groups, GFR increased significantly within 1 week of induction of diabetes (P less than 0.001) and thereafter remained stable. There was no difference in GFR between the treated and untreated groups. 3. Urinary albumin excretion increased progressively in both groups throughout the study. Ramipril treatment reduced albuminuria by approximately 50% at weeks 16 and 24 (P less than 0.01). 4. The amelioration of diabetic albuminuria by ACE inhibition, in the setting of high dietary protein intake, may have important implications for the treatment of human diabetic nephropathy.
Gov't Doc #: 2529067
Journal: Clinical and Experimental Pharmacology & Physiology
Type: Journal Article
Subjects: Albuminuria.drug therapy.etiology
Angiotensin-Converting Enzyme Inhibitors.pharmacology
Bicyclo Compounds.pharmacology
Blood Glucose.metabolism
Blood Pressure.drug effects
Body Weight.drug effects
Bridged Compounds.pharmacology
Diabetes Mellitus, Experimental.complications.urine
Dietary Proteins.pharmacology
Glomerular Filtration Rate
Rats, Inbred WKY
Time Factors
Appears in Collections:Journal articles

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