Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12421
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dc.contributor.authorO'Brien, R Cen
dc.contributor.authorCooper, Mark Een
dc.contributor.authorAllen, Terri Jen
dc.contributor.authorJerums, Georgeen
dc.date.accessioned2015-05-16T02:07:06Z
dc.date.available2015-05-16T02:07:06Z
dc.date.issued1989-08-01en
dc.identifier.citationClinical and Experimental Pharmacology & Physiology; 16(8): 675-80en
dc.identifier.govdoc2529067en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12421en
dc.description.abstract1. Streptozotocin diabetes was induced in Wistar-Kyoto rats fed a 50% protein diet. Animals were randomized to receive either the ACE inhibitor ramipril, 1 mg/L in drinking water (n = 7), or no treatment (n = 7) and were studied for 6 months. Blood glucose, body weight and glomerular filtration rate (GFR) were measured at 0, 1, 4, 8 and 16 weeks of diabetes and urinary albumin excretion was measured every 8 weeks. 2. In both groups, GFR increased significantly within 1 week of induction of diabetes (P less than 0.001) and thereafter remained stable. There was no difference in GFR between the treated and untreated groups. 3. Urinary albumin excretion increased progressively in both groups throughout the study. Ramipril treatment reduced albuminuria by approximately 50% at weeks 16 and 24 (P less than 0.01). 4. The amelioration of diabetic albuminuria by ACE inhibition, in the setting of high dietary protein intake, may have important implications for the treatment of human diabetic nephropathy.en
dc.language.isoenen
dc.subject.otherAlbuminuria.drug therapy.etiologyen
dc.subject.otherAngiotensin-Converting Enzyme Inhibitors.pharmacologyen
dc.subject.otherAnimalsen
dc.subject.otherBicyclo Compounds.pharmacologyen
dc.subject.otherBlood Glucose.metabolismen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherBody Weight.drug effectsen
dc.subject.otherBridged Compounds.pharmacologyen
dc.subject.otherDiabetes Mellitus, Experimental.complications.urineen
dc.subject.otherDieten
dc.subject.otherDietary Proteins.pharmacologyen
dc.subject.otherGlomerular Filtration Rateen
dc.subject.otherMaleen
dc.subject.otherRamiprilen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred WKYen
dc.subject.otherTime Factorsen
dc.titleRamipril reduces albuminuria in diabetic rats fed a high protein diet.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and Experimental Pharmacology & Physiologyen
dc.identifier.affiliationDepartment of Medicine, Austin Hospital, University of Melbourne, Heidelberg, Victoria, Australiaen
dc.description.pages675-80en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2529067en
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptEndocrinology-
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