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Title: Lamotrigine can be beneficial in patients with Dravet syndrome.
Austin Authors: Dalic, Linda;Mullen, Saul A ;Roulet Perez, Eliane;Scheffer, Ingrid E 
Affiliation: Austin Health, Heidelberg, Victoria, Australia
Issue Date: 22-Sep-2014
Publication information: Developmental Medicine and Child Neurology 2014; 57(2): 200-2
Abstract: Dravet syndrome, a severe infantile epilepsy syndrome, is typically resistant to anti-epileptic drugs (AED). Lamotrigine (LTG), an AED that is effective for both focal and generalized seizures, has been reported to aggravate seizures in Dravet syndrome. Therefore, LTG is usually avoided in Dravet syndrome. We describe two adults and a child with Dravet syndrome in whom LTG resulted in decreased seizure duration and frequency. This benefit was highlighted in each patient when LTG was withdrawn after 6 to 15 years, and resulted in an increased frequency of convulsive seizures together with longer seizure duration. A 25-year-old male required hospital admission for frequent seizures for the first time in 7 years, 6 weeks after ceasing LTG. Reintroduction of LTG improved seizure control, suggesting that in some patients with Dravet syndrome, LTG may be beneficial.
Gov't Doc #: 25243660
DOI: 10.1111/dmcn.12593
Type: Journal Article
Subjects: Adolescent
Anticonvulsants.therapeutic use
Epilepsies, Myoclonic.drug therapy.physiopathology
Seizures.drug therapy.physiopathology
Triazines.therapeutic use
Appears in Collections:Journal articles

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