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Title: Influence of BDNF Val66Met on the relationship between physical activity and brain volume.
Austin Authors: Brown, Belinda M;Bourgeat, Pierrick;Peiffer, Jeremiah J;Burnham, Samantha C;Laws, Simon M;Rainey-Smith, Stephanie R;Bartrés-Faz, David;Villemagne, Victor L ;Taddei, Kevin;Rembach, Alan;Bush, Ashley I;Ellis, Kathryn A;Macaulay, S Lance;Rowe, Christopher C ;Ames, David;Masters, Colin L ;Maruff, Paul;Martins, Ralph N
Institutional Author: AIBL Research Group
Affiliation: From the Centre of Excellence for Alzheimer's Disease Research & Care (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), School of Medical Sciences, Edith Cowan University, Joondalup; School of Psychiatry and Clinical Neurosciences (B.M.B., K.T., R.N.M.), University of Western Australia, Perth; McCusker Alzheimer's Research Foundation (B.M.B., S.M.L., S.R.R.-S., K.T., R.N.M.), Perth; CSIRO Preventative Health National Research Flagship (P.B.), The Australian e-Health Research Centre-BioMedIA, Herston; School of Psychology and Exercise Science (J.J.P.), Murdoch University, Perth; CSIRO (S.B.), Mathematics, Informatics and Statistics, Floreat, Australia
The Florey Institute of Neuroscience and Mental Health (V.L.V., A.R., A.B., K.A.E., C.L.M., P.M.), The University of Melbourne, Parkville; National Ageing Research Institute (K.A.E., D.A.), Parkville; CSIRO (S.L.M.), Preventative Health Flagship, CMSE, Parkville; Department of Nuclear Medicine & Centre for PET (V.L.V., C.C.R.), Austin Health, Heidelberg; Academic Unit for Psychiatry of Old Age (K.A.E., D.A.), Department of Psychiatry, The University of Melbourne, St. Vincent's Aged Psychiatry Service, St. George's Hospital, Victoria; and CogState Ltd. (P.M.), Melbourne, Australia
Departament de Psiquiatria i Psicobiologia Clínica (D.B.-F.), Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer, Catalonia, Spain
Issue Date: 3-Sep-2014
Publication information: Neurology 2014; 83(15): 1345-52
Abstract: To investigate the association between habitual physical activity levels and brain temporal lobe volumes, and the interaction with the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism.This study is a cross-sectional analysis of 114 cognitively healthy men and women aged 60 years and older. Brain volumes quantified by MRI were correlated with self-reported physical activity levels. The effect of the interaction between physical activity and the BDNF Val66Met polymorphism on brain structure volumes was assessed. Post hoc analyses were completed to evaluate the influence of the APOE ε4 allele on any found associations.The BDNF Val66Met polymorphism interacted with physical activity to be associated with hippocampal (β = -0.22, p = 0.02) and temporal lobe (β = -0.28, p = 0.003) volumes. In Val/Val homozygotes, higher levels of physical activity were associated with larger hippocampal and temporal lobe volumes, whereas in Met carriers, higher levels of physical activity were associated with smaller temporal lobe volume.The findings from this study support higher physical activity levels in the potential attenuation of age- and disease-related hippocampal and temporal lobe volume loss in Val/Val homozygotes.
DOI: 10.1212/WNL.0000000000000867
Type: Journal Article
Subjects: Aged
Apolipoprotein E2.genetics
Brain-Derived Neurotrophic Factor.genetics
Cross-Sectional Studies
Hippocampus.anatomy & histology
Magnetic Resonance Imaging
Middle Aged
Motor Activity.genetics
Polymorphism, Single Nucleotide.genetics
Temporal Lobe.anatomy & histology
Appears in Collections:Journal articles

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