Please use this identifier to cite or link to this item:
Title: Lymphadenectomy with radical cystectomy at an Australian tertiary referral institution: time trends and impact on oncological outcomes
Austin Authors: Eapen, Renu;Liew, Mun Sem;Tafreshi, Ali;Papa, Nathan P;Lawrentschuk, Nathan;Azad, Arun A;Davis, Ian D;Bolton, Damien M ;Sengupta, Shomik 
Affiliation: Department of Urology, Austin Health, Heidelberg, Victoria, Australia
Ludwig Institute for Cancer Research, Melbourne, Victoria, Australia
Joint Austin-Ludwig Oncology Unit, Austin Health, Heidelberg, Victoria, Australia
Austin Department of Surgery, The University of Melbourne, Heidelberg, Victoria, Australia
Monash University Eastern Health Clinical School, Melbourne, Victoria, Australia
Issue Date: 14-Jul-2014
Publication information: ANZ Journal of Surgery 2015; 85(7-8): 535-539
Abstract: Lymph node dissection (LND) with radical cystectomy (RC) for surgical treatment of invasive urothelial carcinoma of the bladder can improve staging and has possible therapeutic benefit. The aim of this study was to assess utilization and extent of LND with RC at our institution and determine its impact on oncological outcomes.Using surgical databases and hospital coding, clinical and histopathological characteristics of 87 patients who underwent RC at Austin Health between 2004 and 2011 were retrospectively analysed. Associations of predictor variables with LND use and lymph node (LN) status were analysed using logistic regression. Survival analyses were undertaken using Cox proportional hazard models.Fifty-eight (65.9%) patients underwent LND, with a clear trend over time in the proportion of patients undergoing LND (three of seven in 2004 up to 10 of 10 in 2011, P < 0.001) and the median (range) of LN yield from five (2-19) in 2004 to 18 (7-35) in 2011 (P < 0.001). Year of treatment was the only significant predictor (univariately and multivariately) of a patient undergoing LND. Multivariately, a significant association with nodal metastases was found for cN stage and planned extent of LND preoperatively, and pT stage postoperatively. LN status was associated significantly with recurrence-free survival with best outcomes in patients who were node-negative on a pelvic LND. A similar trend was seen for cancer-specific survival (P = 0.053).Over the study period, there was an increase in the use of pelvic LND and LN numbers retrieved during RC. LN status appears to impact on recurrence-free survival, and possibly cancer-specific survival.
Gov't Doc #: 25040795
DOI: 10.1111/ans.12772
ORCID: 0000-0002-3188-1803
Journal: ANZ Journal of Surgery
Type: Journal Article
Subjects: bladder cancer
time trend
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Jan 30, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.