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https://ahro.austin.org.au/austinjspui/handle/1/12286| Title: | Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: an Australian and New Zealand perspective: part 2 new and emerging therapies and their efficacy. | Austin Authors: | Broadley, Simon A;Barnett, Michael H;Boggild, Mike;Brew, Bruce J;Butzkueven, Helmut;Heard, Robert;Hodgkinson, Suzanne;Kermode, Allan G;Lechner-Scott, Jeannette;Macdonell, Richard A L ;Marriott, Mark;Mason, Deborah F;Parratt, John;Reddel, Stephen W;Shaw, Cameron P;Slee, Mark;Spies, Judith;Taylor, Bruce V;Carroll, William M;Kilpatrick, Trevor J;King, John;McCombe, Pamela A;Pollard, John D;Willoughby, Ernest | Affiliation: | Department of Neurology, Austin Health, Heidelberg, Victoria, Australia Hunter Medical Research Institute, The University of Newcastle, New Lambton, NSW, Australia South Western Sydney Clinical School, University of New South Wales, NSW, Australia Westmead Clinical School, University of Sydney, NSW, Australia Department of Neurology and St Vincent's Centre for Applied Medical Research, St Vincent's Hospital, University of New South Wales, Darlinghurst, NSW, Australia Department of Neurology, The Townsville Hospital, Douglas, QLD, Australia Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia School of Medicine, Griffith University, Gold Coast Campus, QLD 4222, Australia School of Medicine, Deakin University, Victoria, Australia Department of Neurology, Gold Coast University Hospital, Southport, QLD, Australia Centre for Neuromuscular and Neurological Disorders, University of Western Australia, WA, Australia Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia Central Clinical School, University of Sydney, NSW, Australia Flinders Medical Centre, Flinders University, SA, Australia Menzies Research Institute, University of Tasmania, TAS, Australia Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia Institute of Immunology and Infectious Diseases, Murdoch University, WA, Australia Department of Neurology, Eastern Health and Monash University, 2/5 Arnold Street, Box Hill VIC 3128, Australia University of Queensland Centre for Clinical Research, QLD, Australia Department of Neurology, Christchurch Hospital, Christchurch, New Zealand. Department of Neurology, Auckland City Hospital, Auckland, New Zealand. |
Issue Date: | 28-Jun-2014 | Publication information: | Journal of Clinical Neuroscience 2014; 21(11): 1847-56 | Abstract: | In Part 2 of this three part review of multiple sclerosis (MS) treatment with a particular focus on the Australian and New Zealand perspective, we review the newer therapies that have recently become available and emerging therapies that have now completed phase III clinical trial programs. We go on to compare the relative efficacies of these newer and emerging therapies alongside the existing therapies. The effectiveness of β-interferon in the treatment of different stages and the different disease courses of MS is critically reviewed with the conclusion that the absolute level of response in term of annualised relapse rates (where relapses occur) and MRI activity are similar, but are disappointing in terms of sustained disability progression for progressive forms of the disease. Finally we review the controversial area of combination therapy for MS. Whilst it remains the case that we have no cure or means of preventing MS, we do have a range of effective therapies that when used appropriately and early in the disease course can have a significant impact on short term and longer term outcomes. | Gov't Doc #: | 24986155 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12286 | DOI: | 10.1016/j.jocn.2014.01.018 | Journal: | Journal of Clinical Neuroscience | URL: | https://pubmed.ncbi.nlm.nih.gov/24986155 | Type: | Journal Article | Subjects: | Evidence-based medicine Guideline Multiple sclerosis Review Treatment |
| Appears in Collections: | Journal articles |
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