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Title: In vivo tau imaging: obstacles and progress.
Austin Authors: Villemagne, Victor L ;Okamura, Nobuyuki
Affiliation: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia, Australia
Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
Issue Date: 1-Jun-2014
Publication information: Alzheimer's & Dementia : the Journal of the Alzheimer's Association; 10(3 Suppl): S254-64
Abstract: The military conflicts of the last decade have highlighted the growing problem of traumatic brain injury in combatants returning from the battlefield. The considerable evidence pointing at the accumulation of tau aggregates and its recognition as a risk factor in neurodegenerative conditions such as Alzheimer's disease have led to a major effort to develop selective tau ligands that would allow research into the physiopathologic underpinnings of traumatic brain injury and chronic traumatic encephalopathy in military personnel and the civilian population. These tracers will allow new insights into tau pathology in the human brain, facilitating research into causes, diagnosis, and treatment of traumatic encephalopathy and major neurodegenerative dementias, such as Alzheimer's disease and some variants of frontotemporal lobar degeneration, in which tau plays a role. The field of selective tau imaging has to overcome several obstacles, some of them associated with the idiosyncrasies of tau aggregation and others related to radiotracer design. A worldwide effort has focused on the development of imaging agents that will allow selective tau imaging in vivo. Recent progress in the development of these tracers is enabling the noninvasive assessment of the extent of tau pathology in the brain, eventually allowing the quantification of changes in tau pathology over time and its relation to cognitive performance, brain volumetrics, and other biomarkers, as well as assessment of efficacy and patient recruitment for antitau therapeutic trials.
DOI: 10.1016/j.jalz.2014.04.013
Type: Journal Article
Subjects: Alzheimer's disease
Chronic traumatic encephalopathy
Molecular neuroimaging
Radiotracer design
Brain.metabolism.radionuclide imaging
Neurodegenerative Diseases.metabolism.radionuclide imaging
Radiopharmaceuticals.chemistry.diagnostic use
tau Proteins.metabolism
Appears in Collections:Journal articles

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