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Title: Comparison of blood pool and extracellular gadolinium chelate for functional MR evaluation of vascular thoracic outlet syndrome.
Austin Authors: Lim, Ruth P ;Bruno, Mary;Rosenkrantz, Andrew B;Kim, Danny C;Mulholland, Thomas;Kwon, Jane;Palfrey, Amy P;Ogedegbe, Olugbenga
Affiliation: St John's University, Department of Psychology, 8000 Utopia Parkway, Jamaica-Queens, NY 11439, USA
New York University School of Medicine, Clinical and Translational Science Institute, 227 E30th St, 8th Floor, New York, NY 10016, USA
The University of Melbourne, School of Medicine, Parkville, Victoria 3010, Australia
New York University School of Medicine, Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, 660 1st Avenue, New York, NY 10016, USA
Austin Health, Department of Radiology, Heidelberg, Victoria 3084, Australia
Issue Date: 30-Apr-2014
Publication information: European Journal of Radiology 2014; 83(7): 1209-15
Abstract: To compare performance of single-injection blood pool agent (gadofosveset trisodium, BPA) against dual-injection extracellular contrast (gadopentetate dimeglumine, ECA) for MRA/MRV in assessment of suspected vascular TOS.Thirty-one patients referred for vascular TOS evaluation were assessed with BPA (n=18) or ECA (n=13) MRA/MRV in arm abduction and adduction. Images were retrospectively assessed for: image quality (1=non-diagnostic, 5=excellent), vessel contrast (1=same signal as muscle, 4=much brighter than muscle) and vascular pathology by two independent readers, with a separate experienced reader providing reference assessment of vascular pathology.Median image quality was diagnostic or better (score ≥ 3) for ECA and BPA at all time points, with BPA image quality superior at abduction late (BPA 4.5, ECA 4, p=0.042) and ECA image quality superior at adduction-early (BPA 4.5; ECA 4.0, p=0.018). High qualitative vessel contrast (mean score ≥ 3) was observed at all time points with both BPA and ECA, with superior BPA vessel contrast at abduction-late (BPA 3.97 ± 0.12; ECA 3.73 ± 0.26, p=0.007) and ECA at adduction-early (BPA 3.42 ± 0.52; ECA 3.96 ± 0.14, p<0.001). Readers readily identified arterial and venous pathology with BPA, similar to ECA examinations.Single-injection BPA MRA/MRV for TOS evaluation demonstrated diagnostic image quality and high vessel contrast, similar to dual-injection ECA imaging, enabling identification of fixed and functional arterial and venous pathology.
Gov't Doc #: 24840478
DOI: 10.1016/j.ejrad.2014.04.018
Journal: European journal of radiology
Type: Journal Article
Subjects: Blood pool agent
Magnetic resonance angiography
Thoracic outlet syndrome
Contrast Media.diagnostic use
Gadolinium.diagnostic use
Gadolinium DTPA.diagnostic use
Image Enhancement.methods
Image Interpretation, Computer-Assisted.methods
Magnetic Resonance Angiography.methods
Magnetic Resonance Imaging.methods
Middle Aged
Observer Variation
Organometallic Compounds.diagnostic use
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Thoracic Outlet Syndrome.pathology
Young Adult
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