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Title: Mistaken identity: granular cell astrocytoma masquerading as histiocytosis of the central nervous system.
Austin Authors: Campbell, Robert N;Liew, Mun Sem;Gan, Hui K ;Cher, Lawrence M 
Affiliation: Department of Neurology, Austin Health, Heidelberg, Victoria, Australia
Joint Austin-Ludwig Oncology Unit, Olivia Newton-John Cancer Wellness and Research Centre, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 6-Feb-2014
Publication information: Journal of Clinical Neuroscience 2014; 21(8): 1457-9
Abstract: Granular cell astrocytoma (GCA) is an uncommon malignant glial tumour that is associated with a poor prognosis. GCA cells have some morphological and immunohistochemical similarities to macrophages. In this case, a small biopsy contained no typical astrocytoma and large rounded lesional cells were interpreted as negative for glial fibrillary acidic protein and S100 and positive for CD68, a commonly used marker for macrophages. A diagnosis of a histiocytosis was made. When the patient failed to respond to first and second line therapy, tumour resection was undertaken and the pathology then showed typical morphologic and immunohistochemical features of glioblastoma (astrocytoma World Health Organization grade IV).
Gov't Doc #: 24594450
DOI: 10.1016/j.jocn.2013.10.037
Journal: Journal of Clinical Neuroscience
Type: Journal Article
Subjects: Erdheim-Chester disease
Granular cell astrocytoma
Biological Markers.metabolism
Diagnosis, Differential
Fatal Outcome
Histiocytosis.diagnosis.drug therapy.metabolism.pathology
Magnetic Resonance Imaging
Middle Aged
Neoplasm Grading
Appears in Collections:Journal articles

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