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Title: Long-term survival and dialysis dependency following acute kidney injury in intensive care: extended follow-up of a randomized controlled trial.
Austin Authors: Gallagher, Martin;Cass, Alan;Bellomo, Rinaldo ;Finfer, Simon;Gattas, David;Lee, Joanne;Lo, Serigne;McGuinness, Shay;Myburgh, John;Parke, Rachael;Rajbhandari, Dorrilyn
Institutional Author: POST-RENAL Study Investigators and the ANZICS Clinical Trials Group
Affiliation: The George Institute for Global Health, Sydney, Australia ; Menzies School of Health Research, Darwin, Australia
The George Institute for Global Health, Sydney, Australia ; St. George Clinical School, University of New South Wales, Sydney, Australia
The George Institute for Global Health, Sydney, Australia
The George Institute for Global Health, Sydney, Australia ; Royal Prince Alfred Hospital, Camperdown, Australia
The George Institute for Global Health, Sydney, Australia ; University of Sydney, Sydney, Australia
Austin Hospital, Heidelberg, Australia
Auckland City Hospital, Auckland, New Zealand.
Issue Date: 11-Feb-2014
Publication information: PLoS Medicine 2014; 11(2): e1001601
Abstract: The incidence of acute kidney injury (AKI) is increasing globally and it is much more common than end-stage kidney disease. AKI is associated with high mortality and cost of hospitalisation. Studies of treatments to reduce this high mortality have used differing renal replacement therapy (RRT) modalities and have not shown improvement in the short term. The reported long-term outcomes of AKI are variable and the effect of differing RRT modalities upon them is not clear. We used the prolonged follow-up of a large clinical trial to prospectively examine the long-term outcomes and effect of RRT dosing in patients with AKI.We extended the follow-up of participants in the Randomised Evaluation of Normal vs. Augmented Levels of RRT (RENAL) study from 90 days to 4 years after randomization. Primary and secondary outcomes were mortality and requirement for maintenance dialysis, respectively, assessed in 1,464 (97%) patients at a median of 43.9 months (interquartile range [IQR] 30.0-48.6 months) post randomization. A total of 468/743 (63%) and 444/721 (62%) patients died in the lower and higher intensity groups, respectively (risk ratio [RR] 1.04, 95% CI 0.96-1.12, p = 0.49). Amongst survivors to day 90, 21 of 411 (5.1%) and 23 of 399 (5.8%) in the respective groups were treated with maintenance dialysis (RR 1.12, 95% CI 0.63-2.00, p = 0.69). The prevalence of albuminuria among survivors was 40% and 44%, respectively (p = 0.48). Quality of life was not different between the two treatment groups. The generalizability of these findings to other populations with AKI requires further exploration.Patients with AKI requiring RRT in intensive care have high long-term mortality but few require maintenance dialysis. Long-term survivors have a heavy burden of proteinuria. Increased intensity of RRT does not reduce mortality or subsequent treatment with dialysis.www.ClinicalTrials.govNCT00221013.
Gov't Doc #: 24523666
DOI: 10.1371/journal.pmed.1001601
Type: Journal Article
Subjects: Acute Kidney Injury.diagnosis.mortality.therapy
Chi-Square Distribution
Intensive Care Units
Kaplan-Meier Estimate
Middle Aged
Multivariate Analysis
New Zealand
Odds Ratio
Proportional Hazards Models
Prospective Studies
Renal Dialysis.adverse effects.mortality
Risk Factors
Time Factors
Treatment Outcome
Appears in Collections:Journal articles

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