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|Title:||18F-fluorodeoxyglucose--positron emission tomography/computed tomography aids staging and predicts mortality in patients with muscle-invasive bladder cancer.||Austin Authors:||Mertens, Laura S;Mir, M Carmen;Scott, Andrew M ;Lee, Sze Ting ;Fioole-Bruining, Annemarie;Vegt, Erik;Vogel, Wouter V;Manecksha, Rustom;Bolton, Damien M ;Davis, Ian D;Horenblas, Simon;van Rhijn, Bas W G;Lawrentschuk, Nathan||Affiliation:||Department of Medicine, Ludwig Institute for Cancer Research, University of Melbourne and Center for PET, Austin Hospital, Melbourne, Australia
Joint Medical Oncology Unit, Austin Hospital, Melbourne, Australia
Department of Surgery, Ludwig Institute for Cancer Research, University of Melbourne and Center for PET, Austin Hospital, Melbourne, Australia
Department of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Department of Urology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
|Issue Date:||1-Feb-2014||Publication information:||Urology; 83(2): 393-8||Abstract:||To investigate the association between extravesical (18)F-fluorodeoxyglucose (FDG) avid lesions on FDG-positron emission tomography/computed tomography (PET/CT) and mortality in patients with muscle-invasive bladder cancer.An international, bi-institutional cohort study of 211 patients with muscle-invasive bladder cancer who underwent staging CT and FDG-PET/CT imaging. On the basis of the presence of extravesical FDG-avid lesions suspicious for malignancy on PET/CT images, patients were divided into a PET/CT-positive and PET/CT-negative group. Data on staging and mortality were retrospectively analyzed from prospective databases. Kaplan-Meier analyses were performed to compare overall (OS) and disease-specific survival (DSS) between the groups. Multivariable Cox regression models were used to investigate the association between extravesical PET/CT lesions and mortality. Extravesical lesions suspicious for malignancy on conventional CT were included in the models.Of the 211 patients, 98 (46.4%) had 1 or more extravesical lesions on PET/CT, 113 (53.5%) had a negative PET/CT. Conventional CT revealed extravesical lesions in 51 patients (24.4%). Median follow-up was 18 months. Patients with a positive PET/CT had a significantly shorter OS and DSS (median OS: 14 vs 50 months, P = .001; DSS: 16 vs 50 months, P <.001). In multivariable analysis, the presence of extravesical lesions on PET/CT was an independent prognostic indicator of mortality (OS: hazard ratio = 3.0, confidence interval 95% 1.7-5.1). This association was not statistically significant for conventional CT (hazard ratio = 1.6 (95% confidence interval 0.9-2.7).On the basis of our results, the presence of extravesical FDG-avid lesions on PET/CT might be considered an independent indicator of mortality.||Gov't Doc #:||24468513||URI:||http://ahro.austin.org.au/austinjspui/handle/1/12063||DOI:||10.1016/j.urology.2013.10.032||Journal:||Urology||URL:||https://pubmed.ncbi.nlm.nih.gov/24468513||Type:||Journal Article||Subjects:||Aged
Fluorodeoxyglucose F18.diagnostic use
Predictive Value of Tests
Tomography, X-Ray Computed
Urinary Bladder Neoplasms.diagnosis.mortality.pathology
|Appears in Collections:||Journal articles|
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